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Matrix metalloproteinase 9 and cellular fibronectin plasma concentrations are predictors of the composite endpoint of length of stay and death in the intensive care unit after severe traumatic brain injury

Publication date2012
Abstract

The relationship between severe traumatic brain injury (TBI) and blood levels of matrix metalloproteinase-9 (MMP-9) or cellular fibronectin (c-Fn) has never been reported. In this study, we aimed to assess whether plasma concentrations of MMP-9 and c-Fn could have predictive values for the composite endpoint of intensive care unit (ICU) length of stay (LOS) of survivors and mortality after severe TBI. Secondary outcomes were the state of consciousness measured with the Glasgow Coma Scale (GCS) of survivors at 14 days and Glasgow Outcome Scale Extended (GOSE) at 3 months.

Keywords
  • Head injury
  • Prediction
  • Outcome
  • Plasmatic biomarker
Citation (ISO format)
COPIN, Jean-Christophe et al. Matrix metalloproteinase 9 and cellular fibronectin plasma concentrations are predictors of the composite endpoint of length of stay and death in the intensive care unit after severe traumatic brain injury. In: Scandinavian journal of trauma, resuscitation and emergency medicine, 2012, vol. 20, p. 83. doi: 10.1186/1757-7241-20-83
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Article (Published version)
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Identifiers
ISSN of the journal1757-7241
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