A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke

del Río-Espínola, Alberto; Fernández-Cadenas, Israel; Giralt, Dolors; Quiroga, Adoracion; Gutiérrez-Agulló, Maria; Quintana, Manuel; Fernández-Álvarez, Patricia; Domingues-Montanari, Sophie; Mendióroz, Maite; Delgado, Pilar; Turck, Natacha; Ruíz, Agustin; Ribó, Marc; Castellanos, Mar; Obach, Victor; Martínez, Sergi; Freijo, Mari Mar; Jiménez-Conde, Jordi; Cuadrado-Godia, Elisa; Roquer, Jaume; Chacón, Pilar; Martí-Fábregas, Joan; Sanchez, Jean-Charles; Montaner, Joan

doi:10.1002/ana.23664

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Title		A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke
Authors		del Río-Espínola, Alberto Fernández-Cadenas, Israel Giralt, Dolors Quiroga, Adoracion Gutiérrez-Agulló, Maria Quintana, Manuel Fernández-Álvarez, Patricia Domingues-Montanari, Sophie Mendióroz, Maite Delgado, Pilar Turck, Natacha Ruíz, Agustin Ribó, Marc Castellanos, Mar Obach, Victor Martínez, Sergi Freijo, Mari Mar Jiménez-Conde, Jordi Cuadrado-Godia, Elisa Roquer, Jaume Chacón, Pilar Martí-Fábregas, Joan Sanchez, Jean-Charles Montaner, Joan show all authors [1 - 24]
Published in		Annals of Neurology. 2012, vol. 72, no. 5, p. 716-29
Abstract		Wide interindividual variability exists in response to tissue plasminogen activator (t-PA) treatment in the acute phase of ischemic stroke. We aimed to find genetic variations associated with hemorrhagic transformation (HT) and mortality rates after t-PA. We then generated a clinical-genetic model for predicting t-PA response.
Keywords		Case-Control Studies — Cohort Studies — Factor XII/genetics/metabolism — Female — Genetic Association Studies — Genotype — Humans — Intracranial Hemorrhages/etiology/genetics — Male — Models, Genetic — Pharmacogenetics — Polymorphism, Single Nucleotide/genetics — Predictive Value of Tests — ROC Curve — Retrospective Studies — Spain/epidemiology — Stroke/drug therapy/genetics/mortality — Time Factors — Tissue Plasminogen Activator/therapeutic use — Tomography, X-Ray Computed — Alpha-Macroglobulins/genetics/metabolism
Identifiers		DOI: 10.1002/ana.23664 PMID: 23280790
Full text		Article (Published version) (467 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research group		Groupe de Protéomique biomédicale (635)
Citation (ISO format)		DEL RÍO-ESPÍNOLA, Alberto et al. A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke. In: Annals of Neurology, 2012, vol. 72, n° 5, p. 716-29. doi: 10.1002/ana.23664 https://archive-ouverte.unige.ch/unige:26871