Scientific article
English

A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke

Published inAnnals of neurology, vol. 72, no. 5, p. 716-729
Publication date2012
Abstract

Wide interindividual variability exists in response to tissue plasminogen activator (t-PA) treatment in the acute phase of ischemic stroke. We aimed to find genetic variations associated with hemorrhagic transformation (HT) and mortality rates after t-PA. We then generated a clinical-genetic model for predicting t-PA response.

Keywords
  • Case-Control Studies
  • Cohort Studies
  • Factor XII/genetics/metabolism
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Intracranial Hemorrhages/etiology/genetics
  • Male
  • Models, Genetic
  • Pharmacogenetics
  • Polymorphism, Single Nucleotide/genetics
  • Predictive Value of Tests
  • ROC Curve
  • Retrospective Studies
  • Spain/epidemiology
  • Stroke/drug therapy/genetics/mortality
  • Time Factors
  • Tissue Plasminogen Activator/therapeutic use
  • Tomography, X-Ray Computed
  • Alpha-Macroglobulins/genetics/metabolism
Research groups
Citation (ISO format)
DEL RÍO-ESPÍNOLA, Alberto et al. A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke. In: Annals of neurology, 2012, vol. 72, n° 5, p. 716–729. doi: 10.1002/ana.23664
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0364-5134
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Creation14/03/2013 11:16:00
First validation14/03/2013 11:16:00
Update09/01/2025 17:08:01
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