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A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke

del Río-Espínola, Alberto
Fernández-Cadenas, Israel
Giralt, Dolors
Quiroga, Adoracion
Gutiérrez-Agulló, Maria
Quintana, Manuel
Fernández-Álvarez, Patricia
Domingues-Montanari, Sophie
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Published in Annals of neurology. 2012, vol. 72, no. 5, p. 716-29
Abstract Wide interindividual variability exists in response to tissue plasminogen activator (t-PA) treatment in the acute phase of ischemic stroke. We aimed to find genetic variations associated with hemorrhagic transformation (HT) and mortality rates after t-PA. We then generated a clinical-genetic model for predicting t-PA response.
Keywords Case-Control StudiesCohort StudiesFactor XII/genetics/metabolismFemaleGenetic Association StudiesGenotypeHumansIntracranial Hemorrhages/etiology/geneticsMaleModels, GeneticPharmacogeneticsPolymorphism, Single Nucleotide/geneticsPredictive Value of TestsROC CurveRetrospective StudiesSpain/epidemiologyStroke/drug therapy/genetics/mortalityTime FactorsTissue Plasminogen Activator/therapeutic useTomography, X-Ray ComputedAlpha-Macroglobulins/genetics/metabolism
PMID: 23280790
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Research group Groupe de Protéomique biomédicale (635)
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DEL RÍO-ESPÍNOLA, Alberto et al. A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke. In: Annals of neurology, 2012, vol. 72, n° 5, p. 716-29. doi: 10.1002/ana.23664 https://archive-ouverte.unige.ch/unige:26871

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Deposited on : 2013-03-19

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