UNIGE document Scientific Article
previous document  unige:2681  next document
add to browser collection
Title

Critical issues in translational and clinical research for the study of new technologies to enhance bone repair

Authors
Goldhahn, Jörg
Mitlak, Bruce
Aspenberg, Per
Kanis, John A.
Reginster, Jean-Yves
Published in Journal of Bone and Joint Surgery. American Volume. 2008, vol. 90 Suppl 1, p. 43-47
Abstract Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of fractures is certainly the option, a fast and uneventful healing process is optimal when fractures do occur. Many new therapeutic strategies have been developed to accelerate fracture-healing or to diminish the complication rate during the course of fracture-healing. However, widely accepted guidelines are needed to demonstrate the positive or negative interactions of bioactive substances, drugs, and other agents that are being used to promote fracture-healing. For each study design, the primary study goal should be indicated. Outcome variables should include both objective and subjective parameters. The guidelines should be harmonized between European and American regulatory authorities to ensure comparability of results of studies and to foster global harmonization of regulatory requirements.
Keywords AdultEuropeFemaleFracture Healing/drug effects/physiologyFractures, Bone/etiology/physiopathology/therapyHumansMaleOsteoporosis/complicationsPractice Guidelines as TopicQuality of LifeUnited States
Identifiers
PMID: 18292356
Full text
Structures
Research groups Nutrition et os (66)
Group for the Respect of Ethics and Excellence in Science
Working Group on Bone Fracture-Healing
Citation
(ISO format)
GOLDHAHN, Jörg et al. Critical issues in translational and clinical research for the study of new technologies to enhance bone repair. In: Journal of Bone and Joint Surgery. American Volume, 2008, vol. 90 Suppl 1, p. 43-47. https://archive-ouverte.unige.ch/unige:2681

174 hits

1 download

Update

Deposited on : 2009-09-15

Export document
Format :
Citation style :