en
Scientific article
English

Critical issues in translational and clinical research for the study of new technologies to enhance bone repair

Published inJournal of bone and joint surgery. American volume, vol. 90 Suppl 1, p. 43-47
Publication date2008
Abstract

Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of fractures is certainly the option, a fast and uneventful healing process is optimal when fractures do occur. Many new therapeutic strategies have been developed to accelerate fracture-healing or to diminish the complication rate during the course of fracture-healing. However, widely accepted guidelines are needed to demonstrate the positive or negative interactions of bioactive substances, drugs, and other agents that are being used to promote fracture-healing. For each study design, the primary study goal should be indicated. Outcome variables should include both objective and subjective parameters. The guidelines should be harmonized between European and American regulatory authorities to ensure comparability of results of studies and to foster global harmonization of regulatory requirements.

Keywords
  • Adult
  • Europe
  • Female
  • Fracture Healing/drug effects/physiology
  • Fractures, Bone/etiology/physiopathology/therapy
  • Humans
  • Male
  • Osteoporosis/complications
  • Practice Guidelines as Topic
  • Quality of Life
  • United States
Research group
Citation (ISO format)
GOLDHAHN, Jörg et al. Critical issues in translational and clinical research for the study of new technologies to enhance bone repair. In: Journal of bone and joint surgery. American volume, 2008, vol. 90 Suppl 1, p. 43–47. doi: 10.2106/JBJS.G.01090
Main files (1)
Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal0021-9355
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Creation09/15/2009 2:24:00 PM
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