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Title

Dietary protein and bone health: roles of amino acid-sensing receptors in the control of calcium metabolism and bone homeostasis
Authors
Conigrave, A. D.
Brown, E. M.
Rizzoli, René
Published in Annual Review of Nutrition. 2008, vol. 28, p. 131-155
Abstract In this article, we review the evidence that dietary protein has a positive influence on bone health, reduces hip fracture risk, and promotes postfracture recovery, and we consider the molecular, cellular, and endocrine bases of the interactions that link protein and calcium metabolism, including effects via IGF-1 and PTH. In addition, we consider the roles of amino acid-sensing mechanisms in coupling dietary protein intake to metabolic change as well as the central role of calcium-sensing receptors (CaRs) in the control of calcium metabolism. Finally, we consider how recently identified broad-spectrum amino acid-sensing receptors from class 3 of the G-protein coupled receptor superfamily including, remarkably, the CaR itself may contribute to the impact of dietary protein on bone.
Keywords Amino Acids/metabolism/physiology — Bone and Bones/metabolism/physiology — Calcium/metabolism — Calcium Signaling — Calcium-Binding Proteins/metabolism/physiology — Dietary Proteins/administration & dosage/metabolism — Energy Metabolism/physiology — Homeostasis — Humans — Parathyroid Hormone/metabolism — Receptors, Amino Acid/metabolism/physiology — Receptors, Calcium-Sensing/metabolism/physiology — Receptors, G-Protein-Coupled/metabolism/physiology — Signal Transduction
Identifiers
PMID: 18466091
Full text
Article (Accepted version) (444 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie
Research group Nutrition et os (66)
Citation
(ISO format) 		CONIGRAVE, A. D., BROWN, E. M., RIZZOLI, René. Dietary protein and bone health: roles of amino acid-sensing receptors in the control of calcium metabolism and bone homeostasis. In: Annual Review of Nutrition, 2008, vol. 28, p. 131-155. doi: 10.1146/annurev.nutr.28.061807.155328 https://archive-ouverte.unige.ch/unige:2678

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Deposited on : 2009-09-15

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