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Title

No Detected Mutations in the Genes for the Amyloid Precursor Protein and Presenilins 1 and 2 in a Swiss Early-Onset Alzheimer's Disease Family with a Dominant Mode of Inheritance
Authors
Savioz, Armand
Leuba, G.
Forsell, C
Lilius, L.
Rossier, Colette
Saini, Krishan
Bouras, Constantin
Lannfelt, L.
Published in Dementia and Geriatric Cognitive Disorders. 1999, vol. 10, no. 6, p. 431-436
Abstract Mutations have been found in more than a hundred early- onset families with Alzheimer's disease (AD) in the genes for the amyloid precursor protein, presenilin 1 and presenilin 2. The object of our investigation was to identify if these mutations or novel ones were operating in a Swiss early-onset AD family (mean age of onset: 53.3 years) with 7 members available, all neuropathologically confirmed. No known or new mutations were detected. Thus, our data support the existence of a yet unknown mutation, or other genes, contributing to familial earlyonset AD.
Keywords Amyloid precursor protein — Early-onset Alzheimer's disease — Mutation screen — Presenilin
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Other version: http://www.karger.com/Article/FullText/17185
Structures
Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Faculté des sciences / Section de biologie / Département de génétique et évolution
Citation
(ISO format) 		SAVIOZ, Armand et al. No Detected Mutations in the Genes for the Amyloid Precursor Protein and Presenilins 1 and 2 in a Swiss Early-Onset Alzheimer's Disease Family with a Dominant Mode of Inheritance. In: Dementia and Geriatric Cognitive Disorders, 1999, vol. 10, n° 6, p. 431-436. https://archive-ouverte.unige.ch/unige:26730

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Deposited on : 2013-03-12

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