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No Detected Mutations in the Genes for the Amyloid Precursor Protein and Presenilins 1 and 2 in a Swiss Early-Onset Alzheimer's Disease Family with a Dominant Mode of Inheritance |
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Published in | Dementia and Geriatric Cognitive Disorders. 1999, vol. 10, no. 6, p. 431-436 | |
Abstract | Mutations have been found in more than a hundred early- onset families with Alzheimer's disease (AD) in the genes for the amyloid precursor protein, presenilin 1 and presenilin 2. The object of our investigation was to identify if these mutations or novel ones were operating in a Swiss early-onset AD family (mean age of onset: 53.3 years) with 7 members available, all neuropathologically confirmed. No known or new mutations were detected. Thus, our data support the existence of a yet unknown mutation, or other genes, contributing to familial earlyonset AD. | |
Keywords | Amyloid precursor protein — Early-onset Alzheimer's disease — Mutation screen — Presenilin | |
Identifiers | DOI: 10.1159/000017185 | |
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![]() ![]() Other version: http://www.karger.com/Article/FullText/17185 |
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Citation (ISO format) | SAVIOZ, Armand et al. No Detected Mutations in the Genes for the Amyloid Precursor Protein and Presenilins 1 and 2 in a Swiss Early-Onset Alzheimer's Disease Family with a Dominant Mode of Inheritance. In: Dementia and Geriatric Cognitive Disorders, 1999, vol. 10, n° 6, p. 431-436. https://archive-ouverte.unige.ch/unige:26730 |