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Title

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

Authors
Ming, Xiu-Fen
Rajapakse, Angana G
Yepuri, Gautham
Xiong, Yuyan
Carvas, João M
Ruffieux, Jean
Wu, Zongsong
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Published in Journal of the American Heart Association. 2012, vol. 1, no. 4, p. e000992
Abstract Macrophage-mediated chronic inflammation is mechanistically linked to insulin resistance and atherosclerosis. Although arginase I is considered antiinflammatory, the role of arginase II (Arg-II) in macrophage function remains elusive. This study characterizes the role of Arg-II in macrophage inflammatory responses and its impact on obesity-linked type II diabetes mellitus and atherosclerosis.
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PMID: 23130157
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Research group L'athérosclérose (665)
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MING, Xiu-Fen et al. Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. In: Journal of the American Heart Association, 2012, vol. 1, n° 4, p. e000992. https://archive-ouverte.unige.ch/unige:26729

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Deposited on : 2013-03-12

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