UNIGE document Scientific Article
previous document  unige:26728  next document
add to browser collection
Title

The natural cardioprotective particle HDL modulates connexin43 gap junction channels

Authors
Rosker, Christian
Rohr, Stephan
Published in Cardiovascular Research. 2012, vol. 93, no. 1, p. 41-9
Abstract High-density lipoprotein (HDL) is known for its cardioprotective properties independent from its cholesterol transport activity. These properties are mediated by activation of kinases such as protein kinase C (PKC). Connexin43 (Cx43) is a gap junction protein present in ventricular cardiomyocytes. PKC-dependent phosphorylation modifies Cx43 gap junction channel properties and is involved in cardioprotection. We hypothesized that cardioprotective properties of HDL may be mediated in part by affecting Cx43 gap junction channels.
Keywords AnimalsCardiotonic Agents/metabolism/pharmacologyCell Communication/drug effectsCell Death/drug effectsCells, CulturedConnexin 43/metabolismGap Junctions/drug effects/metabolismLipoproteins, HDL/metabolism/pharmacologyLysophospholipids/metabolism/pharmacologyMyocardial Reperfusion Injury/drug therapy/pathologyMyocytes, Cardiac/drug effects/metabolismPhosphorylationProtein Kinase C/metabolismRatsRats, Sprague-DawleySphingosine/analogs & derivatives/metabolism/pharmacology
Identifiers
PMID: 21960685
Full text
Article (Published version) (352 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group L'athérosclérose (665)
Citation
(ISO format)
MOREL, Sandrine et al. The natural cardioprotective particle HDL modulates connexin43 gap junction channels. In: Cardiovascular Research, 2012, vol. 93, n° 1, p. 41-9. https://archive-ouverte.unige.ch/unige:26728

184 hits

3 downloads

Update

Deposited on : 2013-03-12

Export document
Format :
Citation style :