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The natural cardioprotective particle HDL modulates connexin43 gap junction channels

Rosker, Christian
Rohr, Stephan
Published in Cardiovascular Research. 2012, vol. 93, no. 1, p. 41-9
Abstract High-density lipoprotein (HDL) is known for its cardioprotective properties independent from its cholesterol transport activity. These properties are mediated by activation of kinases such as protein kinase C (PKC). Connexin43 (Cx43) is a gap junction protein present in ventricular cardiomyocytes. PKC-dependent phosphorylation modifies Cx43 gap junction channel properties and is involved in cardioprotection. We hypothesized that cardioprotective properties of HDL may be mediated in part by affecting Cx43 gap junction channels.
Keywords AnimalsCardiotonic Agents/metabolism/pharmacologyCell Communication/drug effectsCell Death/drug effectsCells, CulturedConnexin 43/metabolismGap Junctions/drug effects/metabolismLipoproteins, HDL/metabolism/pharmacologyLysophospholipids/metabolism/pharmacologyMyocardial Reperfusion Injury/drug therapy/pathologyMyocytes, Cardiac/drug effects/metabolismPhosphorylationProtein Kinase C/metabolismRatsRats, Sprague-DawleySphingosine/analogs & derivatives/metabolism/pharmacology
PMID: 21960685
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Research group L'athérosclérose (665)
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MOREL, Sandrine et al. The natural cardioprotective particle HDL modulates connexin43 gap junction channels. In: Cardiovascular Research, 2012, vol. 93, n° 1, p. 41-9. https://archive-ouverte.unige.ch/unige:26728

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Deposited on : 2013-03-12

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