Scientific article

The natural cardioprotective particle HDL modulates connexin43 gap junction channels

Published inCardiovascular research, vol. 93, no. 1, p. 41-49
Publication date2012

High-density lipoprotein (HDL) is known for its cardioprotective properties independent from its cholesterol transport activity. These properties are mediated by activation of kinases such as protein kinase C (PKC). Connexin43 (Cx43) is a gap junction protein present in ventricular cardiomyocytes. PKC-dependent phosphorylation modifies Cx43 gap junction channel properties and is involved in cardioprotection. We hypothesized that cardioprotective properties of HDL may be mediated in part by affecting Cx43 gap junction channels.

  • Animals
  • Cardiotonic Agents/metabolism/pharmacology
  • Cell Communication/drug effects
  • Cell Death/drug effects
  • Cells, Cultured
  • Connexin 43/metabolism
  • Gap Junctions/drug effects/metabolism
  • Lipoproteins, HDL/metabolism/pharmacology
  • Lysophospholipids/metabolism/pharmacology
  • Myocardial Reperfusion Injury/drug therapy/pathology
  • Myocytes, Cardiac/drug effects/metabolism
  • Phosphorylation
  • Protein Kinase C/metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Sphingosine/analogs & derivatives/metabolism/pharmacology
Citation (ISO format)
MOREL, Sandrine et al. The natural cardioprotective particle HDL modulates connexin43 gap junction channels. In: Cardiovascular research, 2012, vol. 93, n° 1, p. 41–49. doi: 10.1093/cvr/cvr257
Main files (1)
Article (Published version)
ISSN of the journal0008-6363

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