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Lack of association between connexin40 polymorphisms and coronary artery disease |
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Published in | Atherosclerosis. 2012, vol. 222, no. 1, p. 148-53 | |
Abstract | Cx40 is a gap junction protein important for cell-cell communication in the endothelium. Polymorphisms in the promoter region of the human Cx40 gene, -44G>A and +71A>G, were shown to reduce Cx40 transcription by half. As mice with an endothelial-specific deletion of Cx40 are more susceptible to atherosclerosis, this study was designed to discover a correlation between these polymorphisms and atherosclerosis in European populations. | |
Keywords | Aged — Connexins/genetics — Coronary Artery Disease/genetics — Female — Human Umbilical Vein Endothelial Cells — Humans — Hypertension/genetics — Male — Middle Aged — Plaque, Atherosclerotic/pathology — Polymorphism, Genetic — Promoter Regions, Genetic | |
Identifiers | PMID: 22405441 | |
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Research group | L'athérosclérose (665) | |
Citation (ISO format) | PFENNIGER, Anna et al. Lack of association between connexin40 polymorphisms and coronary artery disease. In: Atherosclerosis, 2012, vol. 222, n° 1, p. 148-53. doi: 10.1016/j.atherosclerosis.2012.01.050 https://archive-ouverte.unige.ch/unige:26724 |