Lack of association between connexin40 polymorphisms and coronary artery disease

Pfenniger, Anna; van der Laan, Sander W; Foglia, Bernard; Geindre, Sylvie Françoise; Haefliger, Jacques-Antoine; Winnik, Stephan; Mach, François; Pasterkamp, Gerard; James, Richard William; Kwak, Brenda

doi:10.1016/j.atherosclerosis.2012.01.050

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Title		Lack of association between connexin40 polymorphisms and coronary artery disease
Authors		Pfenniger, Anna van der Laan, Sander W Foglia, Bernard Geindre, Sylvie Françoise Haefliger, Jacques-Antoine Winnik, Stephan Mach, François Pasterkamp, Gerard James, Richard William Kwak, Brenda show all authors [1 - 10]
Published in		Atherosclerosis. 2012, vol. 222, no. 1, p. 148-53
Abstract		Cx40 is a gap junction protein important for cell-cell communication in the endothelium. Polymorphisms in the promoter region of the human Cx40 gene, -44G>A and +71A>G, were shown to reduce Cx40 transcription by half. As mice with an endothelial-specific deletion of Cx40 are more susceptible to atherosclerosis, this study was designed to discover a correlation between these polymorphisms and atherosclerosis in European populations.
Keywords		Aged — Connexins/genetics — Coronary Artery Disease/genetics — Female — Human Umbilical Vein Endothelial Cells — Humans — Hypertension/genetics — Male — Middle Aged — Plaque, Atherosclerotic/pathology — Polymorphism, Genetic — Promoter Regions, Genetic
Identifiers		DOI: 10.1016/j.atherosclerosis.2012.01.050 PMID: 22405441
Full text		Article (Published version) (355 Kb) - Limited access to UNIGE Article (Published version) (195 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		L'athérosclérose (665)
Citation (ISO format)		PFENNIGER, Anna et al. Lack of association between connexin40 polymorphisms and coronary artery disease. In: Atherosclerosis, 2012, vol. 222, n° 1, p. 148-53. doi: 10.1016/j.atherosclerosis.2012.01.050 https://archive-ouverte.unige.ch/unige:26724