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Title

Lack of association between connexin40 polymorphisms and coronary artery disease

Authors
van der Laan, Sander W
Haefliger, Jacques-Antoine
Winnik, Stephan
Pasterkamp, Gerard
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Published in Atherosclerosis. 2012, vol. 222, no. 1, p. 148-53
Abstract Cx40 is a gap junction protein important for cell-cell communication in the endothelium. Polymorphisms in the promoter region of the human Cx40 gene, -44G>A and +71A>G, were shown to reduce Cx40 transcription by half. As mice with an endothelial-specific deletion of Cx40 are more susceptible to atherosclerosis, this study was designed to discover a correlation between these polymorphisms and atherosclerosis in European populations.
Keywords AgedConnexins/geneticsCoronary Artery Disease/geneticsFemaleHuman Umbilical Vein Endothelial CellsHumansHypertension/geneticsMaleMiddle AgedPlaque, Atherosclerotic/pathologyPolymorphism, GeneticPromoter Regions, Genetic
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PMID: 22405441
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Article (Published version) (195 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group L'athérosclérose (665)
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PFENNIGER, Anna et al. Lack of association between connexin40 polymorphisms and coronary artery disease. In: Atherosclerosis, 2012, vol. 222, n° 1, p. 148-53. https://archive-ouverte.unige.ch/unige:26724

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Deposited on : 2013-03-12

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