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Doctoral thesis
Open access
English

Local bioavailability of topical dermatological formulations in vivo, in Man

ContributorsAlberti, Ingo
Defense date2000-09-06
Abstract

Many pharmacodynamic or pharmacokinetic approaches for in vivo assessment of local cutaneous bioavailability are currently available, but there is a growing need for more universal and economic methods. Among these, the direct measurement of the drug concentration in the skin is gaining much importance. This thesis is based on that approach, in particular using the tape stripping technique, which consists of the sequential removal from the treated site of very thin layers of stratum corneum, by the application and removal of an adhesive tape. The method has the advantage of being simple, painless, and relatively non-invasive. Furthermore, due to the reservoir capacity of stratum corneum, drug levels are substantial and correlate with the absorbed amount.

eng
Keywords
  • Dermatopharmacokinetics
  • Tape-stripping
  • Skin
  • Topical drug delivery
  • Mathematical modelling
  • Fourier transform infrared spectroscopy
  • Transepidermal water loss
  • Penetration enhancers
  • Skin occlusion
  • Terbinafine
  • Antifungal drug
  • Stratum corneum
  • Local skin bioavailability
  • Cutaneous drug concentration profile
Citation (ISO format)
ALBERTI, Ingo. Local bioavailability of topical dermatological formulations in vivo, in Man. 2000. doi: 10.13097/archive-ouverte/unige:26416
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Technical informations

Creation01/29/2013 10:41:00 PM
First validation01/29/2013 10:41:00 PM
Update time03/14/2023 8:03:00 PM
Status update03/14/2023 8:03:00 PM
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