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English

Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study

Published inPloS one, vol. 7, no. 9, e46293
Publication date2012
Abstract

Besides its role in controlling the morphology of mitochondria, mitofusin-2 has been proposed to tether mitochondria to the endoplasmic reticulum (ER), based largely on light microscopic analysis. In this study we have examined by electron microscopy the organization of ER and mitochondria in cells expressing or not mitofusin-2. Contrary to previous studies, we observed that loss of mitofusin-2 increased ER-mitochondria juxtaposition. These results suggest that mitofusin-2 does not play a critical role in the juxtapostion of ER and mitochondria, and highlight the essential role of ultrastructural analysis to visualize and measure contact between two intracellular compartments.

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Citation (ISO format)
COSSON, Pierre et al. Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study. In: PloS one, 2012, vol. 7, n° 9, p. e46293. doi: 10.1371/journal.pone.0046293
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ISSN of the journal1932-6203
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Creation11/16/2012 6:41:00 PM
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