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The role of IL-10 in preventing food-induced anaphylaxis

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Published in Expert opinion on biological therapy. 2008, vol. 8, no. 9, p. 1309-17
Abstract BACKGROUND: Food allergy is a common condition resulting in a much impaired quality of life. So far, no clearly effective preventive and therapeutic strategies have been established. However, several options have been tested with promising results. OBJECTIVE: This review examines the potential of various strategies involving an IL-10-mediated effect for tolerance induction to food antigens, mostly for preventing food allergy. METHODS: In addition to a review of the literature, we describe and comment on experiments involving a Lactoccocus lactis strain transfected to secrete murine IL-10 directly into the gut. RESULTS/CONCLUSION: This strain was efficient at preventing subsequent sensitization with a common food allergen. There appears to be a potential for such strategies for the prevention of human food allergy but further investigations will be needed to explore them.
Keywords Anaphylaxis/physiopathology/prevention & controlAnimalsFood Hypersensitivity/physiopathology/prevention & controlHumansInterleukin-10/biosynthesis/therapeutic useIntestines/immunology/metabolism/microbiology/physiopathologyMiceRecombinant Proteins/therapeutic use
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PMID: 18694351
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Article (Author postprint) (1.2 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Pathogenèse et traitement des allergies alimentaires (191)
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FROSSARD, Christophe, EIGENMANN, Philippe. The role of IL-10 in preventing food-induced anaphylaxis. In: Expert opinion on biological therapy, 2008, vol. 8, n° 9, p. 1309-17. https://archive-ouverte.unige.ch/unige:2635

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Deposited on : 2009-09-14

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