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Scientific Article
unige:2635 
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The role of IL-10 in preventing food-induced anaphylaxis |
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| Published in | Expert opinion on biological therapy. 2008, vol. 8, no. 9, p. 1309-17 | |
| Abstract | BACKGROUND: Food allergy is a common condition resulting in a much impaired quality of life. So far, no clearly effective preventive and therapeutic strategies have been established. However, several options have been tested with promising results. OBJECTIVE: This review examines the potential of various strategies involving an IL-10-mediated effect for tolerance induction to food antigens, mostly for preventing food allergy. METHODS: In addition to a review of the literature, we describe and comment on experiments involving a Lactoccocus lactis strain transfected to secrete murine IL-10 directly into the gut. RESULTS/CONCLUSION: This strain was efficient at preventing subsequent sensitization with a common food allergen. There appears to be a potential for such strategies for the prevention of human food allergy but further investigations will be needed to explore them. | |
| Keywords | Anaphylaxis/physiopathology/prevention & control — Animals — Food Hypersensitivity/physiopathology/prevention & control — Humans — Interleukin-10/biosynthesis/therapeutic use — Intestines/immunology/metabolism/microbiology/physiopathology — Mice — Recombinant Proteins/therapeutic use | |
| Identifiers | PMID: 18694351 | |
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| Research group | Pathogenèse et traitement des allergies alimentaires (191) | |
| Citation (ISO format) | FROSSARD, Christophe, EIGENMANN, Philippe. The role of IL-10 in preventing food-induced anaphylaxis. In: Expert opinion on biological therapy, 2008, vol. 8, n° 9, p. 1309-17. doi: 10.1517/14712598.8.9.1309 https://archive-ouverte.unige.ch/unige:2635 |
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