en
Scientific article
English

The role of IL-10 in preventing food-induced anaphylaxis

Published inExpert opinion on biological therapy, vol. 8, no. 9, p. 1309-1317
Publication date2008
Abstract

BACKGROUND: Food allergy is a common condition resulting in a much impaired quality of life. So far, no clearly effective preventive and therapeutic strategies have been established. However, several options have been tested with promising results. OBJECTIVE: This review examines the potential of various strategies involving an IL-10-mediated effect for tolerance induction to food antigens, mostly for preventing food allergy. METHODS: In addition to a review of the literature, we describe and comment on experiments involving a Lactoccocus lactis strain transfected to secrete murine IL-10 directly into the gut. RESULTS/CONCLUSION: This strain was efficient at preventing subsequent sensitization with a common food allergen. There appears to be a potential for such strategies for the prevention of human food allergy but further investigations will be needed to explore them.

Keywords
  • Anaphylaxis/physiopathology/prevention & control
  • Animals
  • Food Hypersensitivity/physiopathology/prevention & control
  • Humans
  • Interleukin-10/biosynthesis/therapeutic use
  • Intestines/immunology/metabolism/microbiology/physiopathology
  • Mice
  • Recombinant Proteins/therapeutic use
Citation (ISO format)
FROSSARD, Christophe, EIGENMANN, Philippe. The role of IL-10 in preventing food-induced anaphylaxis. In: Expert opinion on biological therapy, 2008, vol. 8, n° 9, p. 1309–1317. doi: 10.1517/14712598.8.9.1309
Main files (1)
Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal1744-7682
477views
0downloads

Technical informations

Creation08/27/2009 11:42:00 AM
First validation08/27/2009 11:42:00 AM
Update time03/14/2023 3:11:25 PM
Status update03/14/2023 3:11:25 PM
Last indexation05/02/2024 11:16:06 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack