UNIGE document Scientific Article
previous document  unige:26334  next document
add to browser collection
Title

Platelet proteomics

Authors
Published in Mass Spectrometry Reviews. 2012, vol. 31, no. 2, p. 331-51
Abstract Platelets are small cell fragments, produced by megakaryocytes, in the bone marrow. They play an important role in hemostasis and diverse thrombotic disorders. They are therefore primary targets of antithrombotic therapies. They are implicated in several pathophysiological pathways, such as inflammation or wound repair. In blood circulation, platelets are activated by several pathways including subendothelial matrix and thrombin, triggering the formation of the platelet plug. Studying their proteome is a powerful approach to understand their biology and function. However, particular attention must be paid to different experimental parameters, such as platelet quality and purity. Several technologies are involved during the platelet proteome processing, yielding information on protein identification, characterization, localization, and quantification. Recent technical improvements in proteomics combined with inter-disciplinary strategies, such as metabolomic, transcriptomics, and bioinformatics, will help to understand platelets biological mechanisms. Therefore, a comprehensive analysis of the platelet proteome under different environmental conditions may contribute to elucidate complex processes relevant to platelet function regarding bleeding disorders or platelet hyperreactivity and identify new targets for antiplatelet therapy.
Keywords AnimalsBlood Platelets/chemistry/cytology/metabolism/pathologyHumansPlatelet ActivationProteome/analysis/isolation & purification/metabolismProteomics/methods
Identifiers
PMID: 22009795
Full text
Article (Published version) (634 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Geneva Platelet Group (13)
Citation
(ISO format)
ZUFFEREY BAKOS, Anne et al. Platelet proteomics. In: Mass Spectrometry Reviews, 2012 , vol. 31, n° 2, p. 331-51. https://archive-ouverte.unige.ch/unige:26334

213 hits

2 downloads

Update

Deposited on : 2013-02-11

Export document
Format :
Citation style :