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Scientific article
English

Structure and function of focal adhesions

Published inCurrent opinion in cell biology, vol. 24, no. 1, p. 116-124
Publication date2012
Abstract

Integrin-dependent cell adhesions come in different shapes and serve in different cell types for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular matrix to the formation and stabilization of immunological and chemical synapses. A major challenge consists in the identification of adhesion-specific as well as common regulatory mechanisms, motivating the need for a deeper analysis of protein-protein interactions in the context of intact focal adhesions. Specifically, it is critical to understand how small differences in binding of integrins to extracellular ligands and/or cytoplasmic adapter proteins affect the assembly and function of an entire focal adhesion. By using the talin-integrin pair as a starting point, I would like to discuss how specific protein-protein and protein-lipid interactions can control the behavior and function of focal adhesions. By responding to chemical and mechanical cues several allosterically regulated proteins create a dynamic multifunctional protein network that provides both adhesion to the extracellular matrix as well as intracellular signaling in response to mechanical changes in the cellular environment.

Keywords
  • Actins/metabolism
  • Animals
  • Cell Adhesion
  • Cytoplasm/metabolism
  • Extracellular Matrix/metabolism
  • Focal Adhesions/chemistry/metabolism
  • Humans
  • Integrins/metabolism
  • Signal Transduction
  • Talin/metabolism
Citation (ISO format)
WEHRLE-HALLER, Bernhard. Structure and function of focal adhesions. In: Current opinion in cell biology, 2012, vol. 24, n° 1, p. 116–124. doi: 10.1016/j.ceb.2011.11.001
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Article (Published version)
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Identifiers
ISSN of the journal0955-0674
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Creation11/24/2012 6:29:00 PM
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