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Structure and function of focal adhesions

Published in Current Opinion in Cell Biology. 2012, vol. 24, no. 1, p. 116-24
Abstract Integrin-dependent cell adhesions come in different shapes and serve in different cell types for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular matrix to the formation and stabilization of immunological and chemical synapses. A major challenge consists in the identification of adhesion-specific as well as common regulatory mechanisms, motivating the need for a deeper analysis of protein-protein interactions in the context of intact focal adhesions. Specifically, it is critical to understand how small differences in binding of integrins to extracellular ligands and/or cytoplasmic adapter proteins affect the assembly and function of an entire focal adhesion. By using the talin-integrin pair as a starting point, I would like to discuss how specific protein-protein and protein-lipid interactions can control the behavior and function of focal adhesions. By responding to chemical and mechanical cues several allosterically regulated proteins create a dynamic multifunctional protein network that provides both adhesion to the extracellular matrix as well as intracellular signaling in response to mechanical changes in the cellular environment.
Keywords Actins/metabolismAnimalsCell AdhesionCytoplasm/metabolismExtracellular Matrix/metabolismFocal Adhesions/chemistry/metabolismHumansIntegrins/metabolismSignal TransductionTalin/metabolism
PMID: 22138388
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Research group Migration cellulaire (645)
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WEHRLE-HALLER, Bernhard. Structure and function of focal adhesions. In: Current Opinion in Cell Biology, 2012, vol. 24, n° 1, p. 116-24. doi: 10.1016/j.ceb.2011.11.001 https://archive-ouverte.unige.ch/unige:26304

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Deposited on : 2013-02-08

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