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Role of the cytokine GM-CSF in cell-based anti-tumor immunity: learning from murine models to engineer new therapeutic strategies

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Defense Thèse de privat-docent : Univ. Genève, 2012
Abstract This thesis shows the role of GM-CSF signaling in tumor immunotherapy and the development of genetically modified, GM-CSF secreting, cell-based immunotherapies from several murine models to pilot Phase I clinical trial. Novel strategies to allow clinically relevant immunization schemes are detail with emphasis on encapsulation cell technology, a delivery methods that allows the local release of stable, standarized cytokine such as GM-CSF.
Keywords Cancer GM-CSF Cell-based immunotherapy encapsulation cell technology
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Thesis (7.8 MB) - public document Free access
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Research group La recherche translationnelle en oncologie (654)
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MACH, Nicolas. Role of the cytokine GM-CSF in cell-based anti-tumor immunity: learning from murine models to engineer new therapeutic strategies. Université de Genève. Thèse de privat-docent, 2012. https://archive-ouverte.unige.ch/unige:26302

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Deposited on : 2013-02-07

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