UNIGE document Scientific Article
previous document  unige:26287  next document
add to browser collection

Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases

Sporkert, Frank
Published in Forensic Science International. 2012, vol. 215, no. 1-3, p. 101-4
Abstract Tolperisone (Mydocalm) is a centrally acting muscle relaxant with few sedative side effects that is used for the treatment of chronic pain conditions. We describe three cases of suicidal tolperisone poisoning in three healthy young subjects in the years 2006, 2008 and 2009. In all cases, macroscopic and microscopic autopsy findings did not reveal the cause of death. Systematic toxicological analysis (STA) including immunological tests, screening for volatile substances and blood, urine and gastric content screening by GC-MS and HPLC-DAD demonstrated the presence of tolperisone in all cases. In addition to tolperisone, only the analgesics paracetamol (acetaminophen), ibuprofen and naproxen could be detected. The blood ethanol concentrations were all lower than 0.10 g/kg. Tolperisone was extracted by liquid-liquid extraction using n-chlorobutane as the extraction solvent. The quantification was performed by GC-NPD analysis of blood, urine and gastric content. Tolperisone concentrations of 7.0 mg/l, 14 mg/l and 19 mg/l were found in the blood of the deceased. In the absence of other autopsy findings, the deaths in these three cases were finally explained as a result of lethal tolperisone ingestion. To the best of our knowledge, these three cases are the first reported cases of suicidal tolperisone poisonings.
Keywords Acetaminophen/analysisAdolescentAdultAnalgesicsNon-Narcotic/analysisChromatographyLiquidFemaleForensic ToxicologyGas Chromatography-Mass SpectrometryGastrointestinal Contents/chemistryHumansMuscle RelaxantsCentral/analysis/poisoningSuicideTolperisone/analysis/poisoningYoung Adult
PMID: 21683537
Full text
Article (Published version) (252 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Mangin Patrice (médecine légale) (862)
(ISO format)
SPORKERT, Frank et al. Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases. In: Forensic Science International, 2012, vol. 215, n° 1-3, p. 101-4. https://archive-ouverte.unige.ch/unige:26287

401 hits

0 download


Deposited on : 2013-02-07

Export document
Format :
Citation style :