UNIGE document Scientific Article
previous document  unige:26242  next document
add to browser collection

The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko

Pardo, Bruno
Mottu, Florence
Carraux, Pierre
show hidden authors show all authors [1 - 16]
Published in Toxicological sciences. 2012, vol. 125, no. 1, p. 310-7
Abstract Several million people are exposed to dioxin and dioxin-like compounds, primarily through food consumption. Skin lesions historically called "chloracne" are the most specific sign of abnormal dioxin exposure and classically used as a key marker in humans. We followed for 5 years a man who had been exposed to the most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), at a single oral dose of 5 million-fold more than the accepted daily exposure in the general population. We adopted a molecular medicine approach, aimed at identifying appropriate therapy. Skin lesions, which progressively covered up to 40% of the body surface, were found to be hamartomas, which developed parallel to a complete and sustained involution of sebaceous glands, with concurrent transcriptomic alterations pointing to the inhibition of lipid metabolism and the involvement of bone morphogenetic proteins signaling. Hamartomas created a new compartment that concentrated TCDD up to 10-fold compared with serum and strongly expressed the TCDD-metabolizing enzyme cytochrome P450 1A1, thus representing a potentially significant source of enzymatic activity, which may add to the xenobiotic metabolism potential of the classical organs such as the liver. This historical case provides a unique set of data on the human tissue response to dioxin for the identification of new markers of exposure in human populations. The herein discovered adaptive cutaneous response to TCDD also points to the potential role of the skin in the metabolism of food xenobiotics.
Keywords BiopsyGene Expression/drug effectsGene Expression ProfilingHamartoma/chemically induced/genetics/pathology/therapyHumansMaleMiddle AgedPositron-Emission Tomography and Computed TomographySkin/drug effects/metabolism/pathologySkin Diseases/chemically induced/genetics/pathology/therapyTetrachlorodibenzodioxin/pharmacokinetics/poisoningTreatment Outcome
PMID: 21998131
Full text
Article (Published version) (465 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Groupe Becker Minerva (imagerie ORL) (683)
La recherche en biochimie dermatologique (652)
(ISO format)
SAURAT, Jean-Hilaire et al. The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko. In: Toxicological sciences, 2012, vol. 125, n° 1, p. 310-7. doi: 10.1093/toxsci/kfr223 https://archive-ouverte.unige.ch/unige:26242

571 hits



Deposited on : 2013-02-06

Export document
Format :
Citation style :