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Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease

Plomgaard, P
Published in Diabetes, obesity & metabolism. 2012, vol. 14 Suppl 3, p. 78-84
Abstract Diabetes is a complex disease that affects many organs directly or indirectly. Type 2 diabetes mellitus is characterized by insulin resistance with a relative deficiency in insulin secretion. It has become apparent that inter-organ communication is of great importance in the pathophysiology of diabetes. Far from being an inert tissue in terms of inter-organ communication, it is now recognized that skeletal muscle can secrete so-called myokines that can impact on the function of distant organs/tissues both favourably and unfavourably. We have proposed that communication between insulin-resistant skeletal muscle and β-cells occurs in diabetes. This is a novel route of communication that we further suggest is modified by the prevailing degree of insulin resistance of skeletal muscle. This review focuses on the various myokines [interleukin-6 (IL-6), tumor necrosis factor-α, CXCL10, follistatin and IL-8] which have been identified either after different types of exercise or in the secretome from control and insulin-resistant human skeletal myotubes. We will also summarize studies on the impact of several myokines on pancreatic β-cell proliferation, survival and function.
PMID: 22928567
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PLOMGAARD, P, HALBAN, Philippe A., BOUZAKRI, Karim. Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease. In: Diabetes, obesity & metabolism, 2012, vol. 14 Suppl 3, p. 78-84. doi: 10.1111/j.1463-1326.2012.01641.x https://archive-ouverte.unige.ch/unige:26226

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Deposited on : 2013-02-06

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