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Effects of acceleration in the Gz axis on human cardiopulmonary responses to exercise

Antonutto, Guglielmo
Capelli, Carlo
Linnarsson, Dag
Pendergast, David R
Published in European journal of applied physiology. 2011, vol. 111, no. 12, p. 2907-17
Collection Open Access - Licence nationale Springer
Abstract The aim of this paper was to develop a model from experimental data allowing a prediction of the cardiopulmonary responses to steady-state submaximal exercise in varying gravitational environments, with acceleration in the G(z) axis (a (g)) ranging from 0 to 3 g. To this aim, we combined data from three different experiments, carried out at Buffalo, at Stockholm and inside the Mir Station. Oxygen consumption, as expected, increased linearly with a (g). In contrast, heart rate increased non-linearly with a (g), whereas stroke volume decreased non-linearly: both were described by quadratic functions. Thus, the relationship between cardiac output and a (g) was described by a fourth power regression equation. Mean arterial pressure increased with a (g) non linearly, a relation that we interpolated again with a quadratic function. Thus, total peripheral resistance varied linearly with a (g). These data led to predict that maximal oxygen consumption would decrease drastically as a (g) is increased. Maximal oxygen consumption would become equal to resting oxygen consumption when a (g) is around 4.5 g, thus indicating the practical impossibility for humans to stay and work on the biggest Planets of the Solar System.
Keywords AccelerationAdultAstronautsBlood Pressure/physiologyCardiac Output/physiologyExercise/physiologyExercise Test/methodsGravitationHeart/physiologyHeart Rate/physiologyHumansLung/physiologyMaleOxygen Consumption/physiologySpace FlightStroke Volume/physiology
PMID: 21437604
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Article (Published version) (423 Kb) - public document Free access
Research group Métabolisme énergétique (642)
(ISO format)
BONJOUR, Julien et al. Effects of acceleration in the Gz axis on human cardiopulmonary responses to exercise. In: European journal of applied physiology, 2011, vol. 111, n° 12, p. 2907-17. doi: 10.1007/s00421-011-1917-0 https://archive-ouverte.unige.ch/unige:25868

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Deposited on : 2013-01-23

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