Scientific article
Open access

The CCAN complex: linking centromere specification to control of kinetochore-microtubule dynamics

Published inSeminars in cell & developmental biology, vol. 22, no. 9, p. 946-952
Publication date2011

For over 70 years, chromosomes have been known to oscillate back-and-forth on the metaphase plate. These movements are directed by kinetochores, the microtubule-attachment complexes on centromeres that regulate the dynamics of bound spindle microtubules. Recent evidence shows that the CCAN (Constitutive Centromere Associated Network) kinetochore network, which directly binds centromeric nucleosomes, plays a crucial role in the control of kinetochore microtubule dynamics. Here we review how this 15-subunit protein network functions within the kinetochore machinery, how it may adapt dynamically both in time and in space to the functional requirements necessary for controlled and faithful chromosome movements during cell division, and how this conserved protein network may have evolved in organisms with different cell division machineries.

  • Centromere/metabolism
  • Chromosomal Proteins, Non-Histone/genetics/metabolism
  • Humans
  • Kinetochores/metabolism
  • Microtubules/metabolism
  • Models, Structural
Affiliation Not a UNIGE publication
Citation (ISO format)
MCAINSH, Andrew D, MERALDI, Patrick. The CCAN complex: linking centromere specification to control of kinetochore-microtubule dynamics. In: Seminars in cell & developmental biology, 2011, vol. 22, n° 9, p. 946–952. doi: 10.1016/j.semcdb.2011.09.016
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Article (Published version)
ISSN of the journal1084-9521

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