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Title

Current understanding of the immune mechanisms of food protein-induced enterocolitis syndrome

Authors
Nowak-Węgrzyn, Anna
Published in Expert Review of Clinical Immunology. 2011, vol. 7, no. 3, p. 317-27
Abstract Food protein-induced enterocolitis syndrome (FPIES) is an under-recognized and frequently misdiagnosed non-IgE-mediated food hypersensitivity disorder, characterized by severe vomiting and/or diarrhea. Despite the potential severity of acute reactions, FPIES can be considered self-limiting as avoidance of the incriminating allergen(s) leads to resolution of symptoms. Symptoms typically begin in the first month of life in association with failure to thrive and may progress to acidemia and shock. Although FPIES is well established as a distinct clinical entity, its pathophysiology has not yet been clearly defined and requires further characterization. Several immunologic alterations have been reported in FPIES, suggesting the involvement of antigen-specific T cells and their production of proinflammatory cytokines that regulate the permeability of the intestinal barrier. Humoral immune responses may also be involved in the pathomechanism of FPIES. The aim of this article is to delineate the immunological characteristics of this disorder based on the existing reports and to review the possible pathophysiologic basis of this disease.
Keywords DietEnterocolitis/etiology/immunology/physiopathologyEosinophils/immunologyFood HypersensitivityHumansT-Lymphocytes/immunology
Identifiers
PMID: 21595598
Full text
Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Pathogenèse et traitement des allergies alimentaires (191)
Citation
(ISO format)
CAUBET, Jean-Christoph Roger J-P, NOWAK-WĘGRZYN, Anna. Current understanding of the immune mechanisms of food protein-induced enterocolitis syndrome. In: Expert Review of Clinical Immunology, 2011, vol. 7, n° 3, p. 317-27. doi: 10.1586/eci.11.13 https://archive-ouverte.unige.ch/unige:25794

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Deposited on : 2013-01-21

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