en
Scientific article
Meta-analysis
English

Paediatric liver transplantation for metabolic disorders. Part 1: Liver-based metabolic disorders without liver lesions

Published inClinics and research in hepatology and gastroenterology, vol. 35, no. 3, p. 194-203
Publication date2011
Abstract

Liver-based metabolic disorders account for 10 to 15% of the indications for paediatric liver transplantation. In the last three decades, important progress has been made in the understanding of these diseases, and new therapies have emerged. Concomitantly, medical and surgical innovations have lead to improved results of paediatric liver transplantation, patient survival nowadays exceeding 80% 10-year after surgery with close to normal quality of life in most survivors. This review is a practical update on medical therapy, indications and results of liver transplantation, and potential future therapies, for the main liver-based metabolic disorders in which paediatric liver transplantation may be considered. Part 1 focuses on metabolic based liver disorders without liver lesions, and part 2 on metabolic liver diseases with liver lesions.

Keywords
  • Child
  • Humans
  • Hypercholesterolemia/etiology/surgery
  • Hyperoxaluria/etiology/surgery
  • Hyperoxaluria, Primary
  • Liver Diseases/complications
  • Liver Transplantation
  • Metabolic Diseases/etiology/surgery
  • Transaminases/deficiency
  • Urea Cycle Disorders, Inborn/etiology/surgery
Citation (ISO format)
DARWISH, Ahmed, MCKIERNAN, Patrick, CHARDOT, Christophe. Paediatric liver transplantation for metabolic disorders. Part 1: Liver-based metabolic disorders without liver lesions. In: Clinics and research in hepatology and gastroenterology, 2011, vol. 35, n° 3, p. 194–203. doi: 10.1016/j.clinre.2011.01.006
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal2210-7401
511views
0downloads

Technical informations

Creation12/13/2012 1:06:00 PM
First validation12/13/2012 1:06:00 PM
Update time03/14/2023 7:58:58 PM
Status update03/14/2023 7:58:58 PM
Last indexation01/16/2024 1:01:11 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack