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Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancer

ContributorsFisch, Urs P; Zehnder, Aina; Hirt, Andreas; Niggli, Felix K; Simon, Audrey; Ozsahin, Ayse Hulya; Schlapbach, Luregn J; Ammann, Roland A
Published inSchweizerische medizinische Wochenschrift, vol. 141, w13191
Publication date2011
Abstract

Mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are two key components of the lectin-pathway of complement-activation. Information on the potential role of lectin-pathway components in carcinogenesis versus immune surveillance of cancer is scarce. This study aimed to determine if serum concentrations of MBL and MASP-2 differ between children with cancer and healthy age-matched controls.

Keywords
  • Child
  • Complement Pathway, Mannose-Binding Lectin
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunity, Innate
  • Mannose-Binding Lectin/blood
  • Mannose-Binding Protein-Associated Serine Proteases/analysis
  • Medical Audit
  • Neoplasms/classification
  • Retrospective Studies
  • Switzerland
Affiliation entities
Research groups
Citation (ISO format)
FISCH, Urs P et al. Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancer. In: Schweizerische medizinische Wochenschrift, 2011, vol. 141, p. w13191. doi: 10.4414/smw.2011.13191
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Article (Published version)
accessLevelRestricted
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ISSN of the journal0036-7672
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