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Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease |
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Authors | ||
Collaboration | With : Tempia-Caliera Schaeppi, Michela | |
Published in | Pharmacogenetics and genomics. 2011, vol. 21, no. 9, p. 559-64 | |
Abstract | Inflammatory bowel diseases (IBDs), Crohn's disease, and ulcerative colitis (UC), are multifactorial disorders, characterized by chronic inflammation of the intestine. A number of genetic components have been proposed to contribute to IBD pathogenesis. In this case-control study, we investigated the association between two common vitamin D-binding protein (DBP) genetic variants and IBD susceptibility. These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT>GAG; Asp>Glu) and 420 (ACG>AAG; Thr>Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases. | |
Keywords | Adolescent — Adult — Aged — Aged, 80 and over — Case-Control Studies — Female — Gene Frequency — Genetic Association Studies — Genetic Predisposition to Disease — Genotype — Haplotypes — Humans — Inflammatory Bowel Diseases/genetics — Male — Middle Aged — Polymorphism, Genetic — Polymorphism, Single Nucleotide — Vitamin D-Binding Protein/genetics | |
Identifiers | PMID: 21832969 | |
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Research group | Gastroentérologie et transplantation (pédiatrie) (181) | |
Citation (ISO format) | ELORANTA, Jyrki J et al. Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. In: Pharmacogenetics and genomics, 2011, vol. 21, n° 9, p. 559-64. doi: 10.1097/FPC.0b013e328348f70c https://archive-ouverte.unige.ch/unige:25737 |