Scientific article

Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease

Published inPharmacogenetics and genomics, vol. 21, no. 9, p. 559-564
Publication date2011

Inflammatory bowel diseases (IBDs), Crohn's disease, and ulcerative colitis (UC), are multifactorial disorders, characterized by chronic inflammation of the intestine. A number of genetic components have been proposed to contribute to IBD pathogenesis. In this case-control study, we investigated the association between two common vitamin D-binding protein (DBP) genetic variants and IBD susceptibility. These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT>GAG; Asp>Glu) and 420 (ACG>AAG; Thr>Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases.

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Inflammatory Bowel Diseases/genetics
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Vitamin D-Binding Protein/genetics
Citation (ISO format)
ELORANTA, Jyrki J et al. Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. In: Pharmacogenetics and genomics, 2011, vol. 21, n° 9, p. 559–564. doi: 10.1097/FPC.0b013e328348f70c
Main files (1)
Article (Published version)
ISSN of the journal1744-6872

Technical informations

Creation12/13/2012 3:19:00 PM
First validation12/13/2012 3:19:00 PM
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