en
Scientific article
English

Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease

Published inPharmacogenetics and genomics, vol. 21, no. 9, p. 559-564
Publication date2011
Abstract

Inflammatory bowel diseases (IBDs), Crohn's disease, and ulcerative colitis (UC), are multifactorial disorders, characterized by chronic inflammation of the intestine. A number of genetic components have been proposed to contribute to IBD pathogenesis. In this case-control study, we investigated the association between two common vitamin D-binding protein (DBP) genetic variants and IBD susceptibility. These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT>GAG; Asp>Glu) and 420 (ACG>AAG; Thr>Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Inflammatory Bowel Diseases/genetics
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Vitamin D-Binding Protein/genetics
Citation (ISO format)
ELORANTA, Jyrki J et al. Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. In: Pharmacogenetics and genomics, 2011, vol. 21, n° 9, p. 559–564. doi: 10.1097/FPC.0b013e328348f70c
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1744-6872
561views
0downloads

Technical informations

Creation12/13/2012 3:19:00 PM
First validation12/13/2012 3:19:00 PM
Update time03/14/2023 7:58:35 PM
Status update03/14/2023 7:58:35 PM
Last indexation01/16/2024 1:00:12 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack