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Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease

Eloranta, Jyrki J
Wenger, Christa
Mwinyi, Jessica
Hiller, Christian
Gubler, Christoph
Vavricka, Stephan R
Fried, Michael
Kullak-Ublick, Gerd A
CollaborationWith : Tempia-Caliera Schaeppi, Michela
Published in Pharmacogenetics and genomics. 2011, vol. 21, no. 9, p. 559-64
Abstract Inflammatory bowel diseases (IBDs), Crohn's disease, and ulcerative colitis (UC), are multifactorial disorders, characterized by chronic inflammation of the intestine. A number of genetic components have been proposed to contribute to IBD pathogenesis. In this case-control study, we investigated the association between two common vitamin D-binding protein (DBP) genetic variants and IBD susceptibility. These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT>GAG; Asp>Glu) and 420 (ACG>AAG; Thr>Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases.
Keywords AdolescentAdultAgedAged, 80 and overCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHumansInflammatory Bowel Diseases/geneticsMaleMiddle AgedPolymorphism, GeneticPolymorphism, Single NucleotideVitamin D-Binding Protein/genetics
PMID: 21832969
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Research group Gastroentérologie et transplantation (pédiatrie) (181)
(ISO format)
ELORANTA, Jyrki J et al. Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. In: Pharmacogenetics and genomics, 2011, vol. 21, n° 9, p. 559-64. doi: 10.1097/FPC.0b013e328348f70c https://archive-ouverte.unige.ch/unige:25737

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Deposited on : 2013-01-18

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