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Mechanisms of skeletal muscle weakness

Westerblad, Håkan
Yamada, Takashi
Published in Advances in Experimental Medicine and Biology. 2010, vol. 682, p. 279-96
Abstract Skeletal muscle weakness is an important feature of numerous -pathological conditions and it may also be a component in normal ageing. Decreased muscular strength can be due to decreased muscle mass and/or intrinsic defects in the muscle cells. In this chapter we will discuss decreased force production due to mechanisms intrinsic to skeletal muscle cells. We will mainly use data from mouse disease models to exemplify defects at various sites in the cellular activation-contraction pathway. We will show that depending on the underlying problem, muscle weakness can be due decreased Ca²(+) release from the sarcoplasmic reticulum, reduced myofibrillar Ca²(+) sensitivity and/or decreased ability of the cross-bridges to generate force.
Keywords Acetylcholine/pharmacologyAnimalsCalcium/metabolismDNA-Binding Proteins/deficiency/geneticsDisease Models, AnimalHigh Mobility Group Proteins/deficiency/geneticsMiceMice, KnockoutMotor Neurons/physiologyMuscle Contraction/physiologyMuscle Weakness/genetics/physiopathologyMuscle, Skeletal/drug effects/physiology/physiopathologyMyofibrils/physiology
PMID: 20824532
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Research group Groupe Kayser Bengt (médecine du sport) (306)
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WESTERBLAD, Håkan, PLACE, Nicolas, YAMADA, Takashi. Mechanisms of skeletal muscle weakness. In: Advances in Experimental Medicine and Biology, 2010, vol. 682, p. 279-96. doi: 10.1007/978-1-4419-6366-6_16 https://archive-ouverte.unige.ch/unige:25728

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Deposited on : 2013-01-18

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