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Title

Educational case series: Mechanisms of drug allergy

Authors
Pichler, Werner J
Published in Pediatric Allergy and Immunology. 2011, vol. 22, no. 6, p. 559-67
Abstract Once administered, a drug can activate the immune system by various mechanisms and lead to a large range of clinical manifestations closely related to the type of immune reaction elicited. Administration of the drug can classically result in an immunoglobulin E (IgE)-type sensitization, but can also result in more complex activation of the immune system potentially resulting in severe syndromes, such as the drug-induced hypersensitivity syndrome (DIHS). Although there has been a major increase in our knowledge over the last years, the exact mechanisms of drug allergy are not well understood for most clinical manifestations. A complex interaction between individual characteristics, environmental factors, and the drug itself is usually responsible for adverse reactions to drugs. In this educational review series, we described three cases of drug allergy: first, a child with a typical IgE-mediated drug allergy, second, a child with a non-immediate reaction to penicillin, and in the third patient, we will discuss the drug-induced hypersensitivity syndrome, which is rare but potentially fatal. These cases are correlated to the immune mechanism potentially involved.
Keywords ChildChild, PreschoolDrug Hypersensitivity/immunologyFemaleHumansInfantMale
Identifiers
PMID: 21645118
Full text
Article (Published version) (254 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Pathogenèse et traitement des allergies alimentaires (191)
Citation
(ISO format)
CAUBET, Jean-Christoph Roger J-P, PICHLER, Werner J, EIGENMANN, Philippe. Educational case series: Mechanisms of drug allergy. In: Pediatric Allergy and Immunology, 2011, vol. 22, n° 6, p. 559-67. doi: 10.1111/j.1399-3038.2011.01183.x https://archive-ouverte.unige.ch/unige:25721

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Deposited on : 2013-01-18

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