Scientific article

Educational case series: Mechanisms of drug allergy

Published inPediatric allergy and immunology, vol. 22, no. 6, p. 559-567
Publication date2011

Once administered, a drug can activate the immune system by various mechanisms and lead to a large range of clinical manifestations closely related to the type of immune reaction elicited. Administration of the drug can classically result in an immunoglobulin E (IgE)-type sensitization, but can also result in more complex activation of the immune system potentially resulting in severe syndromes, such as the drug-induced hypersensitivity syndrome (DIHS). Although there has been a major increase in our knowledge over the last years, the exact mechanisms of drug allergy are not well understood for most clinical manifestations. A complex interaction between individual characteristics, environmental factors, and the drug itself is usually responsible for adverse reactions to drugs. In this educational review series, we described three cases of drug allergy: first, a child with a typical IgE-mediated drug allergy, second, a child with a non-immediate reaction to penicillin, and in the third patient, we will discuss the drug-induced hypersensitivity syndrome, which is rare but potentially fatal. These cases are correlated to the immune mechanism potentially involved.

  • Child
  • Child, Preschool
  • Drug Hypersensitivity/immunology
  • Female
  • Humans
  • Infant
  • Male
Citation (ISO format)
CAUBET, Jean-Christoph Roger J-P, PICHLER, Werner J, EIGENMANN, Philippe. Educational case series: Mechanisms of drug allergy. In: Pediatric allergy and immunology, 2011, vol. 22, n° 6, p. 559–567. doi: 10.1111/j.1399-3038.2011.01183.x
Main files (1)
Article (Published version)
ISSN of the journal0905-6157

Technical informations

Creation12/13/2012 11:11:00 AM
First validation12/13/2012 11:11:00 AM
Update time03/14/2023 7:58:27 PM
Status update03/14/2023 7:58:27 PM
Last indexation08/29/2023 5:42:15 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack