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Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder

Publié dansJournal of affective disorders, vol. 132, no. 3, p. 450-453
Date de publication2011
Résumé

Epigenetic changes may play a role in the etiology of psychotic diseases. It has been demonstrated that the serotonin receptor, 5HTR1A, is implicated in schizophrenia (SCZ) and bipolar disorder (BPD). The aim of this study was to investigate the methylation status of a promoter region of the 5HTR1A gene in BPD and SCZ patients.

Mots-clés
  • Adult
  • Bipolar Disorder/genetics/metabolism
  • Brain/metabolism
  • Case-Control Studies
  • CpG Islands
  • DNA Methylation
  • Diagnostic and Statistical Manual of Mental Disorders
  • Epigenesis, Genetic
  • Epigenomics
  • Female
  • Gene Expression
  • Genes
  • Genetic Predisposition to Disease
  • Humans
  • Leukocytes/metabolism
  • Male
  • Middle Aged
  • Promoter Regions, Genetic/genetics
  • Psychotic Disorders/genetics/metabolism
  • Receptor, Serotonin, 5-HT1A/genetics/metabolism
  • Receptors, Serotonin/genetics/metabolism
  • Schizophrenia/genetics/metabolism
  • Young Adult
Citation (format ISO)
CARRARD, Anthony et al. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. In: Journal of affective disorders, 2011, vol. 132, n° 3, p. 450–453. doi: 10.1016/j.jad.2011.03.018
Fichiers principaux (1)
Article (Published version)
accessLevelPublic
Identifiants
ISSN du journal0165-0327
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Informations techniques

Création28/11/2012 14:44:00
Première validation28/11/2012 14:44:00
Heure de mise à jour14/03/2023 19:58:20
Changement de statut14/03/2023 19:58:20
Dernière indexation16/01/2024 00:59:32
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