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Title

Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder

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Published in Journal of Affective Disorders. 2011, vol. 132, no. 3, p. 450-3
Abstract Epigenetic changes may play a role in the etiology of psychotic diseases. It has been demonstrated that the serotonin receptor, 5HTR1A, is implicated in schizophrenia (SCZ) and bipolar disorder (BPD). The aim of this study was to investigate the methylation status of a promoter region of the 5HTR1A gene in BPD and SCZ patients.
Keywords AdultBipolar Disorder/genetics/metabolismBrain/metabolismCase-Control StudiesCpG IslandsDNA MethylationDiagnostic and Statistical Manual of Mental DisordersEpigenesis, GeneticEpigenomicsFemaleGene ExpressionGenesGenetic Predisposition to DiseaseHumansLeukocytes/metabolismMaleMiddle AgedPromoter Regions, Genetic/geneticsPsychotic Disorders/genetics/metabolismReceptor, Serotonin, 5-HT1A/genetics/metabolismReceptors, Serotonin/genetics/metabolismSchizophrenia/genetics/metabolismYoung Adult
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PMID: 21453976
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Research group Génétique psychiatrique (4)
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CARRARD, Anthony et al. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. In: Journal of Affective Disorders, 2011, vol. 132, n° 3, p. 450-3. doi: 10.1016/j.jad.2011.03.018 https://archive-ouverte.unige.ch/unige:25703

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Deposited on : 2013-01-18

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