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Scientific article
Open access
English

Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder

Published inJournal of affective disorders, vol. 132, no. 3, p. 450-453
Publication date2011
Abstract

Epigenetic changes may play a role in the etiology of psychotic diseases. It has been demonstrated that the serotonin receptor, 5HTR1A, is implicated in schizophrenia (SCZ) and bipolar disorder (BPD). The aim of this study was to investigate the methylation status of a promoter region of the 5HTR1A gene in BPD and SCZ patients.

Keywords
  • Adult
  • Bipolar Disorder/genetics/metabolism
  • Brain/metabolism
  • Case-Control Studies
  • CpG Islands
  • DNA Methylation
  • Diagnostic and Statistical Manual of Mental Disorders
  • Epigenesis, Genetic
  • Epigenomics
  • Female
  • Gene Expression
  • Genes
  • Genetic Predisposition to Disease
  • Humans
  • Leukocytes/metabolism
  • Male
  • Middle Aged
  • Promoter Regions, Genetic/genetics
  • Psychotic Disorders/genetics/metabolism
  • Receptor, Serotonin, 5-HT1A/genetics/metabolism
  • Receptors, Serotonin/genetics/metabolism
  • Schizophrenia/genetics/metabolism
  • Young Adult
Citation (ISO format)
CARRARD, Anthony et al. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. In: Journal of affective disorders, 2011, vol. 132, n° 3, p. 450–453. doi: 10.1016/j.jad.2011.03.018
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0165-0327
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720downloads

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