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Mass spectrometry for the evaluation of cardiovascular diseases based on proteomics and lipidomics

Chaurand, Pierre
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Published in Thrombosis and haemostasis. 2011, vol. 106, no. 1, p. 20-33
Abstract The identification and quantification of proteins and lipids is of major importance for the diagnosis, prognosis and understanding of the molecular mechanisms involved in disease development. Owing to its selectivity and sensitivity, mass spectrometry has become a key technique in analytical platforms for proteomic and lipidomic investigations. Using this technique, many strategies have been developed based on unbiased or targeted approaches to highlight or monitor molecules of interest from biomatrices. Although these approaches have largely been employed in cancer research, this type of investigation has been met by a growing interest in the field of cardiovascular disorders, potentially leading to the discovery of novel biomarkers and the development of new therapies. In this paper, we will review the different mass spectrometry-based proteomic and lipidomic strategies applied in cardiovascular diseases, especially atherosclerosis. Particular attention will be given to recent developments and the role of bioinformatics in data treatment. This review will be of broad interest to the medical community by providing a tutorial of how mass spectrometric strategies can support clinical trials.
Keywords Atherosclerosis/diagnosis/drug therapy/metabolismBiological Markers/metabolismCardiovascular Diseases/diagnosis/drug therapy/metabolismClinical Trials as TopicComputational BiologyDrug DiscoveryHumansLipid MetabolismLipids/analysisMass SpectrometryPrognosisProteomics/methods
PMID: 21614412
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Research groups Groupe Mangin Patrice (médecine légale) (862)
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Le rôle du système endocannabinoïde dans l'athérosclérose (882)
Toxicologie analytique et forensique (120)
Traits génétiques complexes (901)
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THOMAS, Aurélien et al. Mass spectrometry for the evaluation of cardiovascular diseases based on proteomics and lipidomics. In: Thrombosis and haemostasis, 2011, vol. 106, n° 1, p. 20-33. doi: 10.1160/TH10-12-0812 https://archive-ouverte.unige.ch/unige:25684

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Deposited on : 2013-01-18

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