Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin

Chen, Lijun; Philippe, Jacques; Unger, Roger H

doi:10.4158/EP11101.OR

Scientific article

English

Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin

ContributorsChen, Lijun; Philippe, Jacques; Unger, Roger H

Published inEndocrine practice, vol. 17, no. 5, p. 819-825

Publication date2011

Abstract

To determine whether glucagon suppression by leptin represents a direct effect on α cells rather than an indirect effect mediated via the hypothalamus.

Keywords

Animals
Cell Line
Cricetinae
Glucagon/secretion
Glucagon-Secreting Cells/drug effects/metabolism
Glucose/pharmacology
Insulin/pharmacology
Leptin/pharmacology
Mice
Receptors, Leptin/genetics/metabolism
Somatostatin/pharmacology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Diabète et régulation des gènes (36)

Citation (ISO format)

CHEN, Lijun, PHILIPPE, Jacques, UNGER, Roger H. Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin. In: Endocrine practice, vol. 17, n° 5, p. 819–825. doi: 10.4158/EP11101.OR

Identifiers

PID : unige:25625
DOI : 10.4158/EP11101.OR
PMID : 21940282

Journal ISSN1530-891X

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Creation15/11/2012 10:00:00

First validation15/11/2012 10:00:00

Update14/03/2023 19:57:50

Status update14/03/2023 19:57:50

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Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin

To determine whether glucagon suppression by leptin represents a direct effect on α cells rather than an indirect effect mediated via the hypothalamus.

Technical informations