Parkinson's disease encompasses a variety of motor and non motor symptoms whose assessment and therapy become more and more complex as the disease progresses. Besides motor fluctuations, dyskinesia, gait impairment and postural instability, patients may exhibit many other problems including orthostatic hypotension, constipation, incontinence, sleep difficulties, depression, behavioural abnormalities and cognitive decline. In this article, current therapeutic strategies aiming at improving these complications in individual patients are briefly reviewed.