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Myofibroblast-mediated adventitial remodeling: an underestimated player in arterial pathology

Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2011, vol. 31, no. 11, p. 2391-6
Abstract The arterial adventitia has been long considered an essentially supportive tissue; however, more and more data suggest that it plays a major role in the modulation of the vascular tone by complex interactions with structures located within intima and media. The purpose of this review is to summarize these data and to describe the mechanisms involved in adventitia/media and adventitia/intima cross-talk. In response to a plethora of stimuli, the adventitia undergoes remodeling processes, resulting in positive (adaptive) remodeling, negative (constrictive) remodeling, or both. The differentiation of the adventitial fibroblast into myofibroblast (MF), a key player of wound healing and fibrosis development, is a hallmark of negative remodeling; this can lead to vessel stenosis and thus contribute to major cardiovascular diseases. The mechanisms of fibroblast-to-MF differentiation and the role of the MF in adventitial remodeling are highlighted herein.
Keywords AnimalsCardiovascular Diseases/pathology/physiopathologyCell Communication/physiologyCell Differentiation/physiologyConnective Tissue/pathology/physiopathologyFibroblasts/pathology/physiologyHumansMyofibroblasts/pathology/physiologyTunica Intima/pathology/physiopathologyTunica Media/pathology/physiopathology
PMID: 21868702
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Research group Bochaton-Piallat Marie-Luce (pathologie et immunologie) (646)
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COEN, Matteo, GABBIANI, Giulio, BOCHATON-PIALLAT, Marie-Luce. Myofibroblast-mediated adventitial remodeling: an underestimated player in arterial pathology. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, vol. 31, n° 11, p. 2391-6. doi: 10.1161/ATVBAHA.111.231548 https://archive-ouverte.unige.ch/unige:25543

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Deposited on : 2013-01-15

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