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Thérapies ciblées du cancer pulmonaire: tests moléculaires à partir d’échantillons cytologiques

Pache, J-C
Published in Revue médicale suisse. 2011, vol. 7, no. 303, p. 1486-90
Abstract Important advances in lung cancer treatment have been made over the last decade. Several drugs designed to target molecular pathways involved in cancer-cell growth and survival have been shown to be effective in a selected fraction (<20%) of non-small cell lung cancer patients. Somatic mutations in several genes (i.e.: EGFR and KRAS) can predict patient's response to targeted therapies. Those mutations are commonly detected on histopathological samples (core-needle biopsy/ surgical resection). However, when tissue biopsies are not available, molecular testing has to be performed on cytological specimens. Issues raised by molecular testing on cytological specimen are discussed in this article.
Keywords Carcinoma, Non-Small-Cell Lung/genetics/pathologyHumansLung Neoplasms/genetics/pathologyMutationProto-Oncogene Proteins/geneticsReceptor, Epidermal Growth Factor/geneticsRas Proteins/genetics
PMID: 21899214
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Other version: http://rms.medhyg.ch/numero-303-page-1486.htm
Research groups Groupe Pache Jean-Claude (pathologie clinique) (658)
Lymphomes MALT et réplication virale (807)
La recherche translationnelle en oncologie (654)
(ISO format)
PUSZTASZERI, Marc et al. Thérapies ciblées du cancer pulmonaire: tests moléculaires à partir d’échantillons cytologiques. In: Revue médicale suisse, 2011, vol. 7, n° 303, p. 1486-90. https://archive-ouverte.unige.ch/unige:25540

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Deposited on : 2013-01-15

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