UNIGE document Scientific Article
previous document  unige:25521  next document
add to browser collection
Title

IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study

Authors
Suppiah, Vijayaprakash
Gaudieri, Silvana
Armstrong, Nicola J
O'Connor, Kate S
Berg, Thomas
Weltman, Martin
Abate, Maria Lorena
Spengler, Ulrich
show hidden authors show all authors [1 - 28]
Published in PLOS Medicine. 2011, vol. 8, no. 9, p. e1001092
Abstract To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%-50% of patients. Interleukin 28B (IL28B) genotype predicts treatment-induced and spontaneous clearance. To improve the predictive value of this genotype, we studied the combined effect of variants of IL28B with human leukocyte antigen C (HLA-C), and its ligands the killer immunoglobulin-like receptors (KIR), which have previously been implicated in HCV viral control.
Keywords AdultAllelesAntiviral Agents/therapeutic useCase-Control StudiesCohort StudiesCross-Sectional StudiesDrug Therapy, CombinationEuropean Continental Ancestry GroupFemaleGenotypeHLA-C Antigens/geneticsHepacivirus/immunology/pathogenicityHepatitis C, Chronic/genetics/immunology/therapy/virologyHumansInterferon-alpha/therapeutic useInterleukins/geneticsKiller Cells, Natural/immunologyMaleMiddle AgedOdds RatioPharmacogenetics/methodsPolymorphism, Single NucleotidePredictive Value of TestsRNA, Viral/analysisReceptors, KIR/geneticsReceptors, KIR2DL3/geneticsRibavirin/therapeutic useTreatment OutcomeViral Load
Identifiers
PMID: 21931540
Full text
Article (Published version) (180 Kb) - public document Free access
Structures
Research group Etudes et traitement de l'hépatite C et B (554)
Citation
(ISO format)
SUPPIAH, Vijayaprakash et al. IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study. In: PLOS Medicine, 2011, vol. 8, n° 9, p. e1001092. https://archive-ouverte.unige.ch/unige:25521

199 hits

35 downloads

Update

Deposited on : 2013-01-15

Export document
Format :
Citation style :