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IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study |
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Published in | PLOS Medicine. 2011, vol. 8, no. 9, e1001092 | |
Abstract | To date, drug response genes have not proved as useful in clinical practice as was anticipated at the start of the genomic era. An exception is in the treatment of chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon-alpha and ribavirin (PegIFN/R). Viral clearance is achieved in 40%-50% of patients. Interleukin 28B (IL28B) genotype predicts treatment-induced and spontaneous clearance. To improve the predictive value of this genotype, we studied the combined effect of variants of IL28B with human leukocyte antigen C (HLA-C), and its ligands the killer immunoglobulin-like receptors (KIR), which have previously been implicated in HCV viral control. | |
Keywords | Adult — Alleles — Antiviral Agents/therapeutic use — Case-Control Studies — Cohort Studies — Cross-Sectional Studies — Drug Therapy, Combination — European Continental Ancestry Group — Female — Genotype — HLA-C Antigens/genetics — Hepacivirus/immunology/pathogenicity — Hepatitis C, Chronic/genetics/immunology/therapy/virology — Humans — Interferon-alpha/therapeutic use — Interleukins/genetics — Killer Cells, Natural/immunology — Male — Middle Aged — Odds Ratio — Pharmacogenetics/methods — Polymorphism, Single Nucleotide — Predictive Value of Tests — RNA, Viral/analysis — Receptors, KIR/genetics — Receptors, KIR2DL3/genetics — Ribavirin/therapeutic use — Treatment Outcome — Viral Load | |
Identifiers | PMID: 21931540 | |
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Research group | Etudes et traitement de l'hépatite C et B (554) | |
Citation (ISO format) | SUPPIAH, Vijayaprakash et al. IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study. In: PLOS Medicine, 2011, vol. 8, n° 9, p. e1001092. doi: 10.1371/journal.pmed.1001092 https://archive-ouverte.unige.ch/unige:25521 |