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Title

Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate volume in posttraumatic stress disorder

Authors
Schulz-Heik, R Jay
Hallmayer, Joachim F
Lin, Xiaoyan
Kaloupek, Danny G
Woodward, Steven H
Published in Biological Psychiatry. 2011, vol. 70, no. 11, p. 1091-6
Abstract Posttraumatic stress disorder (PTSD) is associated with structural and functional compromise of the anterior cingulate cortex (ACC), which may in turn be associated with impairment of its ability to regulate the amygdala. The Val158Met polymorphism in the catechol-O-methyltransferase gene, which substantially influences dopamine inactivation in the frontal lobe in general and in ACC in particular, may moderate ACC integrity in PTSD.
Keywords AdultAnalysis of VarianceCatechol O-Methyltransferase/geneticsFemaleFunctional LateralityGenotypeGyrus Cinguli/pathologyHumansIraq War, 2003 -Magnetic Resonance ImagingMaleMethionine/geneticsMiddle AgedPsychometricsStress Disorders, Post-Traumatic/genetics/pathologyValine/geneticsVietnam
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PMID: 21783175
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Research group Laboratoire d'imagerie et de psychopathologie développementale (693)
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SCHULZ-HEIK, R Jay et al. Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate volume in posttraumatic stress disorder. In: Biological Psychiatry, 2011, vol. 70, n° 11, p. 1091-6. https://archive-ouverte.unige.ch/unige:25511

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Deposited on : 2013-01-14

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