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Title

Incidence of symptomatic and asymptomatic Leishmania donovani infections in high-endemic foci in India and Nepal: a prospective study

Authors
Ostyn, Bart
Gidwani, Kamlesh
Khanal, Basudha
Picado, Albert
Singh, Shri Prakash
Rijal, Suman
Sundar, Shyam
show hidden authors show all authors [1 - 9]
Published in PLOS Neglected Tropical Diseases. 2011, vol. 5, no. 10, p. e1284
Abstract Incidence of Leishmania donovani infection and Visceral Leishmaniasis (VL) was assessed in a prospective study in Indian and Nepalese high-endemic villages. DAT-seroconversion was used as marker of incident infection in 3 yearly surveys. The study population was followed up to month 30 to identify incident clinical cases. In a cohort of 9034 DAT-negative individuals with neither active signs nor history of VL at baseline, 42 VL cases and 375 asymptomatic seroconversions were recorded in the first year, giving an infection:disease ratio of 8.9 to 1. In the 18 months' follow-up, 7 extra cases of VL were observed in the seroconverters group (N=375), against 14 VL cases among the individuals who had not seroconverted in the first year (N=8570) (RR=11.5(4.5<RR<28.3)). Incident asymptomatic L. donovani infection in VL high-endemic foci in India and Nepal is nine times more frequent than incident VL disease. About 1 in 50 of these new but latent infections led to VL within the next 18 months.
Keywords AdolescentAdultAgedAged, 80 and overAgglutination Tests/methodsAntibodies, Protozoan/bloodAsymptomatic DiseasesChildChild, PreschoolCohort StudiesEndemic DiseasesFemaleFollow-Up StudiesHumansIncidenceIndia/epidemiologyInfantInfant, NewbornLeishmania donovani/isolation & purificationLeishmaniasis, Visceral/epidemiology/parasitology/pathologyMaleMiddle AgedNepal/epidemiologyProspective StudiesYoung Adult
Identifiers
PMID: 21991397
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Research group Groupe Jean-Michel Gaspoz (23)
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OSTYN, Bart et al. Incidence of symptomatic and asymptomatic Leishmania donovani infections in high-endemic foci in India and Nepal: a prospective study. In: PLOS Neglected Tropical Diseases, 2011, vol. 5, n° 10, p. e1284. https://archive-ouverte.unige.ch/unige:25492

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Deposited on : 2013-01-14

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