en
Scientific article
Open access
English

Incidence of symptomatic and asymptomatic Leishmania donovani infections in high-endemic foci in India and Nepal: a prospective study

Published inPLoS neglected tropical diseases, vol. 5, no. 10, e1284
Publication date2011
Abstract

Incidence of Leishmania donovani infection and Visceral Leishmaniasis (VL) was assessed in a prospective study in Indian and Nepalese high-endemic villages. DAT-seroconversion was used as marker of incident infection in 3 yearly surveys. The study population was followed up to month 30 to identify incident clinical cases. In a cohort of 9034 DAT-negative individuals with neither active signs nor history of VL at baseline, 42 VL cases and 375 asymptomatic seroconversions were recorded in the first year, giving an infection:disease ratio of 8.9 to 1. In the 18 months' follow-up, 7 extra cases of VL were observed in the seroconverters group (N=375), against 14 VL cases among the individuals who had not seroconverted in the first year (N=8570) (RR=11.5(4.5<28.3)). Incident asymptomatic L. donovani infection in VL high-endemic foci in India and Nepal is nine times more frequent than incident VL disease. About 1 in 50 of these new but latent infections led to VL within the next 18 months.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Agglutination Tests/methods
  • Antibodies, Protozoan/blood
  • Asymptomatic Diseases
  • Child
  • Child, Preschool
  • Cohort Studies
  • Endemic Diseases
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • India/epidemiology
  • Infant
  • Infant, Newborn
  • Leishmania donovani/isolation & purification
  • Leishmaniasis, Visceral/epidemiology/parasitology/pathology
  • Male
  • Middle Aged
  • Nepal/epidemiology
  • Prospective Studies
  • Young Adult
Citation (ISO format)
OSTYN, Bart et al. Incidence of symptomatic and asymptomatic Leishmania donovani infections in high-endemic foci in India and Nepal: a prospective study. In: PLoS neglected tropical diseases, 2011, vol. 5, n° 10, p. e1284. doi: 10.1371/journal.pntd.0001284
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1935-2727
557views
214downloads

Technical informations

Creation10/29/2012 11:24:00 AM
First validation10/29/2012 11:24:00 AM
Update time03/14/2023 7:56:56 PM
Status update03/14/2023 7:56:55 PM
Last indexation08/29/2023 5:37:57 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack