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At least it won't hurt: the personal risks of antibiotic exposure

Published in Current Opinion in Pharmacology. 2011, vol. 11, no. 5, p. 446-52
Abstract This review presents recent evidence regarding the adverse effects of antibiotic therapy mediated by collateral damage to commensal flora. Two major drivers have characterized recent research in this field: new perspectives into human microbiota afforded by next-generation DNA sequencing techniques and ongoing attention to antimicrobial resistance. New molecular techniques have illustrated that antibiotic therapy can disturb human microbiota, and that these changes are associated with infection. Concurrently, epidemiologic studies using patient-level data offer new insights into the role of antibiotics in the emergence, selection and spread of antimicrobial resistance, and Clostridium difficile infection (CDI).
Keywords Anti-Bacterial Agents/pharmacology/therapeutic useBacterial Infections/drug therapy/microbiologyDrug Resistance, BacterialHumansIntestines/microbiologyMetagenome/drug effects
PMID: 21775205
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Research group Groupe Harbarth Stephan (Staphylocoques dorés résistants à la méthicilline) (866)
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STEWARDSON, Andréw James, HUTTNER, Benedikt, HARBARTH, Stéphan Juergen. At least it won't hurt: the personal risks of antibiotic exposure. In: Current Opinion in Pharmacology, 2011, vol. 11, n° 5, p. 446-52. doi: 10.1016/j.coph.2011.06.011 https://archive-ouverte.unige.ch/unige:25490

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Deposited on : 2013-01-14

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