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Connexin implication in the control of the murine beta-cell mass

Caille, Dorothée
Sarro, Rossella
Cederroth, Manon
Haefliger, Jacques-Antoine
Published in Pediatric Research. 2011, vol. 70, no. 2, p. 142-7
Abstract Diabetes develops when the insulin needs of peripheral cells exceed the availability or action of the hormone. This situation results from the death of most beta-cells in type 1 diabetes, and from an inability of the beta-cell mass to adapt to increasing insulin needs in type 2 and gestational diabetes. We analyzed several lines of transgenic mice and showed that connexins (Cxs), the transmembrane proteins that form gap junctions, are implicated in the modulation of the beta-cell mass. Specifically, we found that the native Cx36 does not alter islet size or insulin content, whereas the Cx43 isoform increases both parameters, and Cx32 has a similar effect only when combined with GH. These findings open interesting perspectives for the in vitro and in vivo regulation of the beta-cell mass.
Keywords AnimalsCell SizeConnexin 43/genetics/metabolismConnexins/genetics/metabolismCrosses, GeneticDiabetes Mellitus/metabolismFluorescent Antibody TechniqueGrowth Hormone/metabolismInsulin/metabolismInsulin-Secreting Cells/cytology/metabolismMiceMice, Inbred C57BLMice, TransgenicRadioimmunoassayStatistics, Nonparametric
PMID: 21527868
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Research group Couplage cellulaire et connexines (136)
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KLEE, Philippe et al. Connexin implication in the control of the murine beta-cell mass. In: Pediatric Research, 2011, vol. 70, n° 2, p. 142-7. doi: 10.1203/PDR.0b013e318220f106 https://archive-ouverte.unige.ch/unige:25463

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Deposited on : 2013-01-14

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