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Title

Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims

Authors
Fernandez, Rafael
Ballmann, Eladia
Published in Neuropsychobiology. 2011, vol. 63, no. 4, p. 224-31
Abstract Recent studies have reported alterations in protein kinase B (PKB)/Akt and in its downstream target, glycogen synthase kinase 3β, in depression and suicide. The aim of the present study was to investigate possible impairment of the upstream regulators, namely phosphatidylinositol 3-kinase (PI3K) and PTEN.
Keywords AdultDepressive Disorder, Major/complications/enzymologyFemaleHumansKineticsMaleMiddle AgedPTEN Phosphohydrolase/metabolismPhosphatidylinositol 3-Kinase/metabolismPhosphorylationPrefrontal Cortex/enzymologyProto-Oncogene Proteins c-akt/metabolismSuicide/psychology
Identifiers
PMID: 21422769
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Research groups Génétique psychiatrique (4)
Neurorécepteurs et ARN (672)
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KAREGE, Félicien et al. Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims. In: Neuropsychobiology, 2011, vol. 63, n° 4, p. 224-31. https://archive-ouverte.unige.ch/unige:25420

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Deposited on : 2013-01-11

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