Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims

Karege, Félicien; Perroud, Nader Ali; Burkhardt, Sandra Esther; Fernandez, Rafael; Ballmann, Eladia; La Harpe, Romano; Malafosse, Alain

doi:10.1159/000322145

Professional article

Open access

English

Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims

ContributorsKarege, Félicien; Perroud, Nader Ali

; Burkhardt, Sandra Esther; Fernandez, Rafael; Ballmann, Eladia; La Harpe, Romano; Malafosse, Alain

Published inNeuropsychobiology, vol. 63, no. 4, p. 224-231

Publication date2011

Abstract

Recent studies have reported alterations in protein kinase B (PKB)/Akt and in its downstream target, glycogen synthase kinase 3β, in depression and suicide. The aim of the present study was to investigate possible impairment of the upstream regulators, namely phosphatidylinositol 3-kinase (PI3K) and PTEN.

Keywords

Adult
Depressive Disorder, Major/complications/enzymology
Female
Humans
Kinetics
Male
Middle Aged
PTEN Phosphohydrolase/metabolism
Phosphatidylinositol 3-Kinase/metabolism
Phosphorylation
Prefrontal Cortex/enzymology
Proto-Oncogene Proteins c-akt/metabolism
Suicide/psychology

Affiliation

Research group

Citation (ISO format)

KAREGE, Félicien et al. Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims. In: Neuropsychobiology, 2011, vol. 63, n° 4, p. 224–231. doi: 10.1159/000322145

Article (Published version)

Identifiers

PID : unige:25420
DOI : 10.1159/000322145
PMID : 21422769

ISSN of the journal0302-282X

608views

530downloads

Creation11/28/2012 2:54:00 PM

First validation11/28/2012 2:54:00 PM

Update time03/14/2023 7:56:25 PM

Status update03/14/2023 7:56:24 PM

Last indexation08/29/2023 5:36:36 AM

Archive ouverte UNIGE

Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims

Technical informations