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Mechanisms of aneuploidy and its suppression by tumour suppressor proteins

Thoma, Claudio R
Toso, Alberto
Krek, Wilhelm
Published in Swiss Medical Weekly. 2011, vol. 141, p. w13170
Abstract Aneuploidy, as a result of numerical changes in chromosome number, was observed in tumours almost a century ago. The molecular mechanisms underlying this phenomenon and their impact on tumour development are still poorly understood. A series of recent observations provide direct linkages between the normal function of tumour suppressor proteins and the suppression of aneuploidy. The prospects that these findings offer for understanding the role of aneuploidy in cancer are discussed in this review.
Keywords Adenomatous Polyposis Coli Protein/genetics/metabolismAneuploidyChromosomal Instability/geneticsGenes, cdcHumansNeoplasms/genetics/metabolismRepressor Proteins/genetics/metabolismRetinoblastoma Protein/genetics/metabolismTumor Suppressor Protein p53/genetics/metabolismTumor Suppressor Proteins/genetics/metabolismVon Hippel-Lindau Tumor Suppressor Protein/genetics/metabolism
PMID: 21384284
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Article (Published version) (421 Kb) - public document Free access
Research group Groupe Meraldi Patrick (physiologie cellulaire et métabolisme) (922)
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THOMA, Claudio R et al. Mechanisms of aneuploidy and its suppression by tumour suppressor proteins. In: Swiss Medical Weekly, 2011, vol. 141, p. w13170. https://archive-ouverte.unige.ch/unige:25394

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Deposited on : 2013-01-11

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