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The electroencephalographic fingerprint of sleep is genetically determined: a twin study

De Gennaro, Luigi
Marzano, Cristina
Finelli, Luca A.
Pasqualetti, Patrizio
Ferrara, Michele
Bertini, Mario
Rossini, Paolo Maria
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Published in Annals of Neurology. 2008, vol. 64, no. 4, p. 455-60
Abstract Humans have an individual profile of the electroencephalographic power spectra at the 8 to 16 Hz frequency during non-rapid eye movement sleep that is stable over time and resistant to experimental perturbations. We tested the hypothesis that this electroencephalographic "fingerprint" is genetically determined, by recording 40 monozygotic and dizygotic twins during baseline and recovery sleep after prolonged wakefulness. We show a largely greater similarity within monozygotic than dizygotic pairs, resulting in a heritability estimate of 96%, not influenced by sleep need and intensity. If replicated, these results will establish the electroencephalographic profile during sleep as one of the most heritable traits of humans.
Keywords AdultElectroencephalographyFemaleHumansMalePolysomnographySleep/geneticsTwins, Dizygotic/physiologyTwins, Monozygotic/physiologyWakefulness/geneticsYoung Adult
PMID: 18688819
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Research group Génétique psychiatrique (4)
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DE GENNARO, Luigi et al. The electroencephalographic fingerprint of sleep is genetically determined: a twin study. In: Annals of neurology, 2008, vol. 64, n° 4, p. 455-60. doi: 10.1002/ana.21434 https://archive-ouverte.unige.ch/unige:2539

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Deposited on : 2009-08-28

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