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Title

Inhaled nitric oxide for acute respiratory distress syndrome and acute lung injury in adults and children: a systematic review with meta-analysis and trial sequential analysis

Authors
Brok, Jesper
Møller, Ann M
Wetterslev, Jørn
Published in Anesthesia and Analgesia. 2011, vol. 112, no. 6, p. 1411-21
Abstract Acute hypoxemic respiratory failure, defined as acute lung injury and acute respiratory distress syndrome, are critical conditions associated with frequent mortality and morbidity in all ages. Inhaled nitric oxide (iNO) has been used to improve oxygenation, but its role remains controversial. We performed a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials (RCTs). We searched CENTRAL, Medline, Embase, International Web of Science, LILACS, the Chinese Biomedical Literature Database, and CINHAL (up to January 31, 2010). Additionally, we hand-searched reference lists, contacted authors and experts, and searched registers of ongoing trials. Two reviewers independently selected all parallel group RCTs comparing iNO with placebo or no intervention and extracted data related to study methods, interventions, outcomes, bias risk, and adverse events. All trials, irrespective of blinding or language status were included. Retrieved trials were evaluated with Cochrane methodology. Disagreements were resolved by discussion. Our primary outcome measure was all-cause mortality. We performed subgroup and sensitivity analyses to assess the effect of iNO in adults and children and on various clinical and physiological outcomes. We assessed the risk of bias through assessment of trial methodological components. We assessed the risk of random error by applying trial sequential analysis.
Keywords Acute Lung Injury/metabolism/mortalityAdministration, InhalationAdultChildHumansIntervention StudiesNitric Oxide/administration & dosageOxygen/metabolismPlacebosRandomized Controlled Trials as TopicRespiratory Distress Syndrome, Adult/mortality/therapyRiskTreatment Outcome
Identifiers
PMID: 21372277
Full text
Article (Published version) (3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Harbarth Stephan (Staphylocoques dorés résistants à la méthicilline) (866)
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(ISO format)
AFSHARI, Arash et al. Inhaled nitric oxide for acute respiratory distress syndrome and acute lung injury in adults and children: a systematic review with meta-analysis and trial sequential analysis. In: Anesthesia and Analgesia, 2011, vol. 112, n° 6, p. 1411-21. https://archive-ouverte.unige.ch/unige:25384

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Deposited on : 2013-01-11

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