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Candidate genes for temporal lobe epilepsy: a replication study

Perroud, Nader
Crespel, Arielle
Lambercy, Carmen
Published in Neurological sciences. 2008, vol. 29, no. 6, p. 397-403
Collection Open Access - Licence nationale Springer
Abstract The objective of this study is to replicate previously published results regarding the involvement of several susceptibility genes in temporal lobe epilepsy (TLE): interleukin 1beta (IL-1beta), interleukin 1beta (IL-1alpha), interleukin 1RA (IL-1RA), apolipoprotein E (ApoE) and prodynorphin (PDYN). We used a case-control approach comparing several polymorphisms within these candidate genes between unrelated TLE patients and matched controls. We were thus able to confirm the role of ApoE, IL-1alpha and IL-1RA genes in TLE disease, but failed to confirm the involvement of IL-1beta and PDYN. This failure should be interpreted with caution, as this may be due to the small size of our study groups and the resultant lack of statistical power.
Keywords AdolescentAdultApolipoproteins E/geneticsCase-Control StudiesChildCohort StudiesDNA Mutational AnalysisEnkephalins/geneticsEpilepsy, Temporal Lobe/genetics/immunology/physiopathologyGene FrequencyGenetic Markers/geneticsGenetic Predisposition to Disease/geneticsGenetic ScreeningGenotypeHumansInterleukin 1 Receptor Antagonist Protein/geneticsInterleukin-1alpha/geneticsInterleukin-1beta/geneticsInterleukins/geneticsPolymorphism, Genetic/geneticsProtein Precursors/genetics
PMID: 19066720
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Research group Génétique psychiatrique (4)
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SALZMANN, Annick et al. Candidate genes for temporal lobe epilepsy: a replication study. In: Neurological sciences, 2008, vol. 29, n° 6, p. 397-403. doi: 10.1007/s10072-008-1060-9 https://archive-ouverte.unige.ch/unige:2538

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Deposited on : 2009-08-28

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