Scientific article
Open access

Candidate genes for temporal lobe epilepsy: a replication study

Published inNeurological sciences, vol. 29, no. 6, p. 397-403
  • Open Access - Licence nationale Springer
Publication date2008

The objective of this study is to replicate previously published results regarding the involvement of several susceptibility genes in temporal lobe epilepsy (TLE): interleukin 1beta (IL-1beta), interleukin 1beta (IL-1alpha), interleukin 1RA (IL-1RA), apolipoprotein E (ApoE) and prodynorphin (PDYN). We used a case-control approach comparing several polymorphisms within these candidate genes between unrelated TLE patients and matched controls. We were thus able to confirm the role of ApoE, IL-1alpha and IL-1RA genes in TLE disease, but failed to confirm the involvement of IL-1beta and PDYN. This failure should be interpreted with caution, as this may be due to the small size of our study groups and the resultant lack of statistical power.

  • Adolescent
  • Adult
  • Apolipoproteins E/genetics
  • Case-Control Studies
  • Child
  • Cohort Studies
  • DNA Mutational Analysis
  • Enkephalins/genetics
  • Epilepsy, Temporal Lobe/genetics/immunology/physiopathology
  • Gene Frequency
  • Genetic Markers/genetics
  • Genetic Predisposition to Disease/genetics
  • Genetic Screening
  • Genotype
  • Humans
  • Interleukin 1 Receptor Antagonist Protein/genetics
  • Interleukin-1alpha/genetics
  • Interleukin-1beta/genetics
  • Interleukins/genetics
  • Polymorphism, Genetic/genetics
  • Protein Precursors/genetics
Citation (ISO format)
SALZMANN, Annick et al. Candidate genes for temporal lobe epilepsy: a replication study. In: Neurological sciences, 2008, vol. 29, n° 6, p. 397–403. doi: 10.1007/s10072-008-1060-9
Main files (1)
Article (Published version)
ISSN of the journal1590-1874

Technical informations

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