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Scientific article
Meta-analysis
English

Mechanisms of hepatitis C virus-related insulin resistance

Contributors

Negro, Francesco

Published in

Clinics and research in hepatology and gastroenterology, vol. 35, no. 5, p. 358-363

Publication date

2011

Abstract

The hepatitis C virus (HCV) infection has been shown to have direct and/or indirect effects on glucose metabolism, leading to insulin resistance and, in predisposed individuals, type 2 diabetes. This is supported by several experimental, clinical and epidemiological data. The detailed molecular events leading to insulin resistance in HCV-infected patients are unclear. HCV infects primarily the liver and, to a very minor extent, mononuclear cells. Direct interactions between HCV products and the hepatocyte insulin signaling pathway have been reported by several authors. However, recent evidence supports the existence of a significant extrahepatic component of HCV-induced insulin resistance. Thus, the molecular pathogenesis of glucose metabolism disturbances observed in hepatitis C is much more complex than expected. The clinical management of such condition remains empirical.

Keywords

  • Hepatitis C, Chronic/metabolism
  • Humans
  • Insulin Resistance

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

NEGRO, Francesco. Mechanisms of hepatitis C virus-related insulin resistance. In: Clinics and research in hepatology and gastroenterology, 2011, vol. 35, n° 5, p. 358–363. doi: 10.1016/j.clinre.2011.01.011

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

2210-7401
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Technical informations

Creation

01/11/2012 12:51:00

First validation

01/11/2012 12:51:00

Update

14/03/2023 19:56:04

Status update

14/03/2023 19:56:04

Last indexation

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