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Mechanisms of hepatitis C virus-related insulin resistance

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Published in Clinics and Research in Hepatology and Gastroenterology. 2011, vol. 35, no. 5, p. 358-63
Abstract The hepatitis C virus (HCV) infection has been shown to have direct and/or indirect effects on glucose metabolism, leading to insulin resistance and, in predisposed individuals, type 2 diabetes. This is supported by several experimental, clinical and epidemiological data. The detailed molecular events leading to insulin resistance in HCV-infected patients are unclear. HCV infects primarily the liver and, to a very minor extent, mononuclear cells. Direct interactions between HCV products and the hepatocyte insulin signaling pathway have been reported by several authors. However, recent evidence supports the existence of a significant extrahepatic component of HCV-induced insulin resistance. Thus, the molecular pathogenesis of glucose metabolism disturbances observed in hepatitis C is much more complex than expected. The clinical management of such condition remains empirical.
Keywords Hepatitis C, Chronic/metabolismHumansInsulin Resistance
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PMID: 21354385
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Article (Published version) (232 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Etudes et traitement de l'hépatite C et B (554)
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NEGRO, Francesco. Mechanisms of hepatitis C virus-related insulin resistance. In: Clinics and Research in Hepatology and Gastroenterology, 2011, vol. 35, n° 5, p. 358-63. https://archive-ouverte.unige.ch/unige:25375

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Deposited on : 2013-01-11

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