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Renal fibrosis and proteomics: current knowledge and still key open questions for proteomic investigation

Published inJournal of proteomics, vol. 74, no. 10, p. 1855-1870
Publication date2011
Abstract

Renal tubulo-interstitial fibrosis is a non-specific process, representing the final common pathway for all kidney diseases, irrespective of their initial cause, histological injury, or etiology, leading to gradual expansion of the fibrotic mass which destroys the normal structure of the tissue and results in organ dysfunction and, ultimately, in end-stage organ failure. Proteomic studies of the fibrotic pathophysiological mechanisms have been performed in cell cultures, animal models and human tissues, addressing some of the key issues. This article will review proteomic contribution to the raising current knowledge on renal fibrosis biology and also mention seminal open questions to which proteomic techniques and proteomists could fruitfully contribute.

Keywords
  • Animals
  • Anoxia/complications
  • Blood Glucose/physiology
  • Cyclosporine/adverse effects
  • Diabetic Nephropathies/complications/physiopathology
  • Fibrosis
  • Glomerulonephritis/physiopathology
  • Humans
  • Kidney/pathology
  • Kidney Diseases/pathology/physiopathology
  • Kidney Failure, Chronic/physiopathology
  • Proteomics/methods
  • Transforming Growth Factor beta/physiology
Citation (ISO format)
PRUNOTTO, Marco et al. Renal fibrosis and proteomics: current knowledge and still key open questions for proteomic investigation. In: Journal of proteomics, 2011, vol. 74, n° 10, p. 1855–1870. doi: 10.1016/j.jprot.2011.05.031
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ISSN of the journal1874-3919
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