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Renal fibrosis and proteomics: current knowledge and still key open questions for proteomic investigation

Ghiggeri, Gianmarco
Bruschi, Maurizio
Hocher, Berthold
Chaykovska, Lyubov
Berrera, Marco
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Published in Journal of Proteomics. 2011, vol. 74, no. 10, p. 1855-70
Abstract Renal tubulo-interstitial fibrosis is a non-specific process, representing the final common pathway for all kidney diseases, irrespective of their initial cause, histological injury, or etiology, leading to gradual expansion of the fibrotic mass which destroys the normal structure of the tissue and results in organ dysfunction and, ultimately, in end-stage organ failure. Proteomic studies of the fibrotic pathophysiological mechanisms have been performed in cell cultures, animal models and human tissues, addressing some of the key issues. This article will review proteomic contribution to the raising current knowledge on renal fibrosis biology and also mention seminal open questions to which proteomic techniques and proteomists could fruitfully contribute.
Keywords AnimalsAnoxia/complicationsBlood Glucose/physiologyCyclosporine/adverse effectsDiabetic Nephropathies/complications/physiopathologyFibrosisGlomerulonephritis/physiopathologyHumansKidney/pathologyKidney Diseases/pathology/physiopathologyKidney Failure, Chronic/physiopathologyProteomics/methodsTransforming Growth Factor beta/physiology
PMID: 21642026
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Research groups Analyse protéomique et Analyse génomique des maladies rénales (659)
Chimie et protéomique clinique (270)
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PRUNOTTO, Marco et al. Renal fibrosis and proteomics: current knowledge and still key open questions for proteomic investigation. In: Journal of proteomics, 2011, vol. 74, n° 10, p. 1855-70. doi: 10.1016/j.jprot.2011.05.031 https://archive-ouverte.unige.ch/unige:25365

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Deposited on : 2013-01-10

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