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Title

Cerebral blood flow effects of acute intravenous heroin administration

Authors
Noss, Roger S.
Hämmig, Robert
Wielepp, Peter
Bundeli, Petra
Heidbreder, Rebeca
Kinser, Jane A.
Brenneisen, Rudolf
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Published in European Neuropsychopharmacology. 2008, vol. 18, no. 4, p. 278-85
Abstract We examined acute effects of intravenous diacetylmorphine (heroin) administration - which induces a characteristic biphasic response: A short rush-sensation associated with intense pleasurable feelings followed by a subjectively different period of euphoria on cerebral blood flow. This was assessed in nine male heroin dependent patients participating in a heroin maintenance program in a setting resembling everyday pattern of heroin abuse. 99mTc-HMPAO was administered 45 s (rush) and 15 min (euphoria) after administration of i.v. heroin and 45 s after administration of saline (placebo). Plasma concentration of diacetylmorphine and its metabolites were measured with high-pressure liquid chromatography (HPLC). Compared to the euphoria condition, rush was associated with blood flow increase in the left posterior cerebellar lobe, left anterior cingulate gyrus and right precuneus. Our results are in line with recent reports indicating that the cerebellum is an important component in functional brain systems subserving sensory and motor integration, learning, modulation of affect, motivation and social behaviour, which all play important roles in reinforcing properties of opioids.
Keywords AdultBrain/radionuclide imagingCerebrovascular Circulation/drug effectsEuphoria/drug effects/physiologyHeroin/blood/pharmacologyHeroin Dependence/physiopathology/psychology/radionuclide imagingHumansImage Processing, Computer-AssistedInjections, IntravenousLinear ModelsMaleModels, StatisticalNarcotics/blood/pharmacologyOxygen/bloodRadiopharmaceuticals/diagnostic useTechnetium Tc 99m Exametazime/diagnostic useTomography, Emission-Computed, Single-Photon
Identifiers
PMID: 18207374
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Research group Evaluation et traitement de la dépression (690)
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KOSEL, Markus Mathaus et al. Cerebral blood flow effects of acute intravenous heroin administration. In: European Neuropsychopharmacology, 2008, vol. 18, n° 4, p. 278-85. https://archive-ouverte.unige.ch/unige:2536

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Deposited on : 2009-08-28

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