The Absence of the Vomer in the First and Early Second Trimester of Pregnancy - A New Marker of Trisomy 21 and Trisomy 13

Mihailovic, T; Stimec, Bojan; Terzic, M; Dmitrovic, A; Micic, J

doi:10.1055/s-0029-1245951

Scientific article

English

The Absence of the Vomer in the First and Early Second Trimester of Pregnancy - A New Marker of Trisomy 21 and Trisomy 13

Contributors

Mihailovic, T; Stimec, Bojan

; Terzic, M; Dmitrovic, A; Micic, J

Published in

Ultraschall in der Medizin, vol. 33, no. 07, p. E68-E74

Publication date

2011

Abstract

PURPOSE: The aim of this study was to measure the two frontomaxillo-facial (FMF) angles: the FMF-vomer (FMF-v) and the FMF-palate (FMF-p), and to visualize the vomer in the 1 (st) and early 2 (nd) trimester, in order to ascertain whether they can be used as markers for trisomy 21 and trisomy 13. MATERIALS AND METHODS: A 2D ultrasound scan was performed in the 340 normal and 12 abnormal pregnancies, using the linear, convex and endovaginal probes. RESULTS: We visualized the FMF angles within 1 to 5 minutes in 253 (72 %) of cases by using the linear probe. FMF-v angle was significantly smaller that the FMF-p angle (79.8° vs. 89.7°, 71.5° vs. 84.5° for the two trimesters, respectively), and that the value of both angles decreased in the second trimester. There was not one single case of trisomy in which vomer could be identified in the 1 (st) and early 2 (nd) trimester. The FMF-p angle failed to present difference between normal cases and the ones with trisomy (89.5°). There was not one single case of trisomy (21 or 13) in which vomer or FMF-v could be identified in the first or early second trimester. The diagnostic accuracy of vomer as a marker for trisomy was 0.985. CONCLUSION: If the vomer cannot be visualized in the 1 (st) and early 2 (nd) trimester, it is important to check the karyotype, and it is not necessary to measure the FMF-p angle. The high resolution probe (L 12 - 5 Mhz) enables easier assessment of the vomer.

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

UNIGE research groups

Anatomie clinique (134)

Citation (ISO format)

MIHAILOVIC, T et al. The Absence of the Vomer in the First and Early Second Trimester of Pregnancy - A New Marker of Trisomy 21 and Trisomy 13. In: Ultraschall in der Medizin, 2011, vol. 33, n° 07, p. E68–E74. doi: 10.1055/s-0029-1245951

Article (Published version)

Identifiers

PID : unige:25329
DOI : 10.1055/s-0029-1245951
PMID : 21294068

Journal ISSN

0172-4614

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Creation

18/10/2012 15:48:00

First validation

18/10/2012 15:48:00

Update

14/03/2023 19:55:47

Status update

14/03/2023 19:55:47

Last indexation

30/10/2024 08:22:02

The Absence of the Vomer in the First and Early Second Trimester of Pregnancy - A New Marker of Trisomy 21 and Trisomy 13

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation