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Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function |
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Authors | ![]() | |
Published in | Respiration. 2011, vol. 81, no. 6, p. 499-510 | |
Abstract | Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by progressive airflow limitation and significant extrapulmonary (systemic) effects that lead to co-morbid conditions, though the pathomechanism of COPD is largely undetermined. Alveolar macrophages (AM) derived from peripheral monocytes (MO) appear to play a key role in initiating and/or sustaining disease progression. | |
Keywords | Adult — Aged — Biological Markers/metabolism — Bronchoalveolar Lavage Fluid/immunology — Female — Forced Expiratory Volume — Gene Expression Profiling — Humans — Macrophages, Alveolar/metabolism — Male — Middle Aged — Monocytes/metabolism — Oligonucleotide Array Sequence Analysis — Pulmonary Disease, Chronic Obstructive/genetics/metabolism — Reverse Transcriptase Polymerase Chain Reaction | |
Identifiers | DOI: 10.1159/000324297 PMID: 21430361 | |
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Research group | Groupe Reith Walter (pathologie et immunologie) (282) | |
Citation (ISO format) | POLISKA, Szilard et al. Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function. In: Respiration, 2011, vol. 81, n° 6, p. 499-510. doi: 10.1159/000324297 https://archive-ouverte.unige.ch/unige:25264 |