Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function

Poliska, Szilard; Csanky, Eszter; Szanto, Attila; Szatmari, Istvan; Mesko, Bertalan; Szeles, Lajos; Dezso, Balazs; Scholtz, Beata; Podani, Janos; Kilty, Iain; Takacs, Laszlo; Nagy, Laszlo

doi:10.1159/000324297

Scientific article

English

Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function

ContributorsPoliska, Szilard; Csanky, Eszter; Szanto, Attila; Szatmari, Istvan; Mesko, Bertalan; Szeles, Lajos; Dezso, Balazs; Scholtz, Beata; Podani, Janos; Kilty, Iain; Takacs, Laszlo; Nagy, Laszlo

Published inRespiration, vol. 81, no. 6, p. 499-510

Publication date2011

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by progressive airflow limitation and significant extrapulmonary (systemic) effects that lead to co-morbid conditions, though the pathomechanism of COPD is largely undetermined. Alveolar macrophages (AM) derived from peripheral monocytes (MO) appear to play a key role in initiating and/or sustaining disease progression.

Keywords

Adult
Aged
Biological Markers/metabolism
Bronchoalveolar Lavage Fluid/immunology
Female
Forced Expiratory Volume
Gene Expression Profiling
Humans
Macrophages, Alveolar/metabolism
Male
Middle Aged
Monocytes/metabolism
Oligonucleotide Array Sequence Analysis
Pulmonary Disease, Chronic Obstructive/genetics/metabolism
Reverse Transcriptase Polymerase Chain Reaction

Affiliation Not a UNIGE publication

Research group

Groupe Reith Walter (pathologie et immunologie) (282)

Citation (ISO format)

POLISKA, Szilard et al. Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function. In: Respiration, 2011, vol. 81, n° 6, p. 499–510. doi: 10.1159/000324297

Article (Published version)

Identifiers

PID : unige:25264
DOI : 10.1159/000324297
PMID : 21430361

ISSN of the journal0025-7931

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Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function

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