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Title

Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function

Authors
Poliska, Szilard
Csanky, Eszter
Szanto, Attila
Szatmari, Istvan
Mesko, Bertalan
Dezso, Balazs
Scholtz, Beata
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Published in Respiration. 2011, vol. 81, no. 6, p. 499-510
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by progressive airflow limitation and significant extrapulmonary (systemic) effects that lead to co-morbid conditions, though the pathomechanism of COPD is largely undetermined. Alveolar macrophages (AM) derived from peripheral monocytes (MO) appear to play a key role in initiating and/or sustaining disease progression.
Keywords AdultAgedBiological Markers/metabolismBronchoalveolar Lavage Fluid/immunologyFemaleForced Expiratory VolumeGene Expression ProfilingHumansMacrophages, Alveolar/metabolismMaleMiddle AgedMonocytes/metabolismOligonucleotide Array Sequence AnalysisPulmonary Disease, Chronic Obstructive/genetics/metabolismReverse Transcriptase Polymerase Chain Reaction
Identifiers
PMID: 21430361
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Article (Published version) (682 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Reith Walter (pathologie et immunologie) (282)
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POLISKA, Szilard et al. Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function. In: Respiration, 2011, vol. 81, n° 6, p. 499-510. https://archive-ouverte.unige.ch/unige:25264

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Deposited on : 2013-01-09

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