Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function

Poliska, Szilard; Csanky, Eszter; Szanto, Attila; Szatmari, Istvan; Mesko, Bertalan; Szeles, Lajos; Dezso, Balazs; Scholtz, Beata; Podani, Janos; Kilty, Iain; Takacs, Laszlo; Nagy, Laszlo

doi:10.1159/000324297

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Title		Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function
Authors		Poliska, Szilard Csanky, Eszter Szanto, Attila Szatmari, Istvan Mesko, Bertalan Szeles, Lajos Dezso, Balazs Scholtz, Beata Podani, Janos Kilty, Iain Takacs, Laszlo Nagy, Laszlo show all authors [1 - 12]
Published in		Respiration. 2011, vol. 81, no. 6, p. 499-510
Abstract		Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by progressive airflow limitation and significant extrapulmonary (systemic) effects that lead to co-morbid conditions, though the pathomechanism of COPD is largely undetermined. Alveolar macrophages (AM) derived from peripheral monocytes (MO) appear to play a key role in initiating and/or sustaining disease progression.
Keywords		Adult — Aged — Biological Markers/metabolism — Bronchoalveolar Lavage Fluid/immunology — Female — Forced Expiratory Volume — Gene Expression Profiling — Humans — Macrophages, Alveolar/metabolism — Male — Middle Aged — Monocytes/metabolism — Oligonucleotide Array Sequence Analysis — Pulmonary Disease, Chronic Obstructive/genetics/metabolism — Reverse Transcriptase Polymerase Chain Reaction
Identifiers		DOI: 10.1159/000324297 PMID: 21430361
Full text		Article (Published version) (682 Kb) - Limited access to UNIGE
Research group		Groupe Reith Walter (pathologie et immunologie) (282)
Citation (ISO format)		POLISKA, Szilard et al. Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function. In: Respiration, 2011, vol. 81, n° 6, p. 499-510. doi: 10.1159/000324297 https://archive-ouverte.unige.ch/unige:25264