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Update on screening and clinical diagnosis of meticillin-resistant Staphylococcus aureus (MRSA)

Hawkey, Peter M
Tenover, Fred
Stefani, Stefania
Pantosti, Annalisa
Struelens, Marc J
Published in International Journal of Antimicrobial Agents. 2011, vol. 37, no. 2, p. 110-7
Abstract Based on the failure of conventional control strategies, some experts and public health officials have promoted active screening to detect asymptomatic carriers of meticillin-resistant Staphylococcus aureus (MRSA) as an effective prevention strategy. Data regarding the (cost-) effectiveness of MRSA screening have recently grown and have produced mixed results. Several clinical studies have not only provided conflicting findings but have also raised numerous issues about the appropriate populations for universal versus targeted screening, screening method(s) and intervention(s). It must also be emphasised that screening alone is not effective. Results should be followed by appropriate interventions to reduce the risk of MRSA transmission and infection. We believe a reasonable approach in most European hospitals with an MRSA on-admission prevalence of <5% is to use targeted rather than universal screening (predominantly with chromogenic media, except for high-risk units and critically ill patients for whom molecular tests could be cost effective), after carefully considering the local MRSA epidemiology, infection control practices and vulnerability of the patient population. This strategy is likely to be cost effective if linked to prompt institution of control measures.
Keywords Bacteriological Techniques/methodsCarrier State/diagnosis/drug therapy/microbiologyDiagnostic Tests, Routine/methodsHumansMass Screening/methodsMethicillin-Resistant Staphylococcus aureus/isolation & purificationStaphylococcal Infections/diagnosis/drug therapy/microbiology
PMID: 21163628
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Research group Groupe Harbarth Stephan (Staphylocoques dorés résistants à la méthicilline) (866)
(ISO format)
HARBARTH, Stéphan Juergen et al. Update on screening and clinical diagnosis of meticillin-resistant Staphylococcus aureus (MRSA). In: International Journal of Antimicrobial Agents, 2011, vol. 37, n° 2, p. 110-7. doi: 10.1016/j.ijantimicag.2010.10.022 https://archive-ouverte.unige.ch/unige:25238

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Deposited on : 2013-01-09

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