Systemic ghrelin and reward: effect of cholinergic blockade

Disse, Emmanuel; Bussier Peteut, Anne-Lise; Deblon, Nicolas; Pfluger, P T; Tschöp, M H; Laville, M; Rohner-Jeanrenaud, Françoise

doi:10.1016/j.physbeh.2010.12.006

Scientific article

English

Systemic ghrelin and reward: effect of cholinergic blockade

Contributors

Disse, Emmanuel; Bussier Peteut, Anne-Lise; Deblon, Nicolas; Pfluger, P T; Tschöp, M H; Laville, M; Rohner-Jeanrenaud, Françoise

Published in

Physiology & behavior, vol. 102, no. 5, p. 481-484

Publication date

2011

Abstract

Ghrelin is one of the most potent orexigens known to date. Recent data suggested that ghrelin is involved in reward-mediated processes such as the rewarding value of food. Whereas the neuronal pathways by which ghrelin regulates energy balance are well described, those involved in ghrelin-induced reward are still confusing. Therefore, we attempted to delineate the involvement of physiological and pharmacological rises in plasma ghrelin in the modulation of food reward seeking behaviours, using the classical conditioned place preference (CPP) procedure in C57BL6J mice, as well as in mice lacking the ghrelin receptor (GHSR1a -/-). We also determined whether these effects on reward-related behaviours could be partly mediated by cholinergic pathways by pre-treating mice with mecamylamine.

Keywords

Animals
Caloric Restriction/methods
Choice Behavior/drug effects/physiology
Conditioning, Classical/drug effects/physiology
Ghrelin/antagonists & inhibitors/blood/genetics/pharmacology/physiology
Mecamylamine/pharmacology
Mice
Mice, Inbred C57BL
Mice, Knockout
Motor Activity/physiology
Nicotinic Antagonists/pharmacology
Reward

UNIGE affiliation entities

UNIGE research groups

Homéostasie métabolique (649)

Citation (ISO format)

DISSE, Emmanuel et al. Systemic ghrelin and reward: effect of cholinergic blockade. In: Physiology & behavior, 2011, vol. 102, n° 5, p. 481–484. doi: 10.1016/j.physbeh.2010.12.006

Article (Published version)

Identifiers

PID : unige:25237
DOI : 10.1016/j.physbeh.2010.12.006
PMID : 21163280

Journal ISSN

0031-9384

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Creation

27/11/2012 14:37:00

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27/11/2012 14:37:00

Update

14/03/2023 19:55:07

Status update

14/03/2023 19:55:07

Last indexation

30/10/2024 08:19:29

Systemic ghrelin and reward: effect of cholinergic blockade

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation