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Systemic ghrelin and reward: effect of cholinergic blockade

Pfluger, P T
Tschöp, M H
Laville, M
Published in Physiology & behavior. 2011, vol. 102, no. 5, p. 481-4
Abstract Ghrelin is one of the most potent orexigens known to date. Recent data suggested that ghrelin is involved in reward-mediated processes such as the rewarding value of food. Whereas the neuronal pathways by which ghrelin regulates energy balance are well described, those involved in ghrelin-induced reward are still confusing. Therefore, we attempted to delineate the involvement of physiological and pharmacological rises in plasma ghrelin in the modulation of food reward seeking behaviours, using the classical conditioned place preference (CPP) procedure in C57BL6J mice, as well as in mice lacking the ghrelin receptor (GHSR1a -/-). We also determined whether these effects on reward-related behaviours could be partly mediated by cholinergic pathways by pre-treating mice with mecamylamine.
Keywords AnimalsCaloric Restriction/methodsChoice Behavior/drug effects/physiologyConditioning, Classical/drug effects/physiologyGhrelin/antagonists & inhibitors/blood/genetics/pharmacology/physiologyMecamylamine/pharmacologyMiceMice, Inbred C57BLMice, KnockoutMotor Activity/physiologyNicotinic Antagonists/pharmacologyReward
PMID: 21163280
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Research group Homéostasie métabolique (649)
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DISSE, Emmanuel et al. Systemic ghrelin and reward: effect of cholinergic blockade. In: Physiology & behavior, 2011, vol. 102, n° 5, p. 481-4. doi: 10.1016/j.physbeh.2010.12.006 https://archive-ouverte.unige.ch/unige:25237

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Deposited on : 2013-01-09

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