Scientific article
English

Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis

Published inArthritis and rheumatism, vol. 63, no. 4, p. 1097-1105
Publication date2011
Abstract

The nonsynonymous polymorphism rs763361 of the CD226 gene, which encodes DNAX accessory molecule 1, which is involved in T cell costimulation pathways, has recently been identified as a genetic risk factor for autoimmunity. The purpose of this study was to test for association of the CD226 rs763361 polymorphism with systemic sclerosis (SSc) in European Caucasian populations.

Keywords
  • Adult
  • Aged
  • Antigens, Differentiation, T-Lymphocyte/genetics
  • Case-Control Studies
  • European Continental Ancestry Group/genetics
  • Female
  • France
  • Genetic Predisposition to Disease/genetics
  • Genotype
  • Germany
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Polymorphism, Genetic/genetics
  • Risk Factors
  • Scleroderma, Systemic/ethnology/genetics/pathology
  • T-Lymphocytes/pathology
Citation (ISO format)
DIEUDÉ, P et al. Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis. In: Arthritis and rheumatism, 2011, vol. 63, n° 4, p. 1097–1105. doi: 10.1002/art.30204
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0004-3591
681views
0downloads

Technical informations

Creation12/12/2012 17:27:00
First validation12/12/2012 17:27:00
Update14/03/2023 19:55:11
Status update14/03/2023 19:55:10
Last indexation30/10/2024 08:19:28
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack