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Title

Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis

Authors
Dieudé, P
Guedj, M
Wipff, J
Revillod, L
Riemekasten, G
Matucci-Cerinic, M
Melchers, I
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Published in Arthritis and Rheumatism. 2011, vol. 63, no. 4, p. 1097-105
Abstract The nonsynonymous polymorphism rs763361 of the CD226 gene, which encodes DNAX accessory molecule 1, which is involved in T cell costimulation pathways, has recently been identified as a genetic risk factor for autoimmunity. The purpose of this study was to test for association of the CD226 rs763361 polymorphism with systemic sclerosis (SSc) in European Caucasian populations.
Keywords AdultAgedAntigens, Differentiation, T-Lymphocyte/geneticsCase-Control StudiesEuropean Continental Ancestry Group/geneticsFemaleFranceGenetic Predisposition to Disease/geneticsGenotypeGermanyHumansItalyMaleMiddle AgedPolymorphism, Genetic/geneticsRisk FactorsScleroderma, Systemic/ethnology/genetics/pathologyT-Lymphocytes/pathology
Identifiers
PMID: 21162102
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Research group La matrice extracellulaire (651)
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DIEUDÉ, P et al. Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis. In: Arthritis and Rheumatism, 2011, vol. 63, n° 4, p. 1097-105. https://archive-ouverte.unige.ch/unige:25236

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Deposited on : 2013-01-09

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