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Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis

Yamada, Takashi
Kosterina, Natalia
Ostberg, Therese
Zhang, Shi-Jin
Grundtman, Cecilia
Erlandsson-Harris, Helena
Lundberg, Ingrid E
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Published in Arthritis and rheumatism. 2009, vol. 60, no. 11, p. 3280-9
Abstract Progressive muscle weakness is a common feature in patients with rheumatoid arthritis (RA). However, little is known about whether the intrinsic contractile properties of muscle fibers are affected in RA. This study was undertaken to investigate muscle contractility and the myoplasmic free Ca2+ concentration ([Ca2+](i)) in the soleus, a major postural muscle, in mice with collagen-induced arthritis (CIA).
Keywords Actins/metabolismAnimalsArthritis, Experimental/metabolism/physiopathologyArthritis, Rheumatoid/metabolism/physiopathologyBody Weight/physiologyDisease Models, AnimalFemaleMiceMice, Inbred DBAMuscle Contraction/physiologyMuscle, Skeletal/physiopathologyMyofibrils/physiologyMyosin Heavy Chains/metabolismNitric Oxide Synthase/metabolismOxidation-ReductionPeroxynitrous Acid/metabolismSuperoxide Dismutase/metabolismTime Factors
PMID: 19877058
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Research group Groupe Kayser Bengt (médecine du sport) (306)
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YAMADA, Takashi et al. Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis. In: Arthritis and rheumatism, 2009, vol. 60, n° 11, p. 3280-9. doi: 10.1002/art.24907 https://archive-ouverte.unige.ch/unige:25233

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Deposited on : 2013-01-09

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