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Scientific article
English

Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis

Published inArthritis and rheumatism, vol. 60, no. 11, p. 3280-3289
Publication date2009
Abstract

Progressive muscle weakness is a common feature in patients with rheumatoid arthritis (RA). However, little is known about whether the intrinsic contractile properties of muscle fibers are affected in RA. This study was undertaken to investigate muscle contractility and the myoplasmic free Ca2+ concentration ([Ca2+](i)) in the soleus, a major postural muscle, in mice with collagen-induced arthritis (CIA).

Keywords
  • Actins/metabolism
  • Animals
  • Arthritis, Experimental/metabolism/physiopathology
  • Arthritis, Rheumatoid/metabolism/physiopathology
  • Body Weight/physiology
  • Disease Models, Animal
  • Female
  • Mice
  • Mice, Inbred DBA
  • Muscle Contraction/physiology
  • Muscle, Skeletal/physiopathology
  • Myofibrils/physiology
  • Myosin Heavy Chains/metabolism
  • Nitric Oxide Synthase/metabolism
  • Oxidation-Reduction
  • Peroxynitrous Acid/metabolism
  • Superoxide Dismutase/metabolism
  • Time Factors
Citation (ISO format)
YAMADA, Takashi et al. Impaired myofibrillar function in the soleus muscle of mice with collagen-induced arthritis. In: Arthritis and rheumatism, 2009, vol. 60, n° 11, p. 3280–3289. doi: 10.1002/art.24907
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Article (Published version)
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Identifiers
ISSN of the journal0004-3591
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